Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Immunological markers of lung disease due to non-tuberculous mycobacteria

    Access Status
    Fulltext not available
    Authors
    Lim, A.
    Allison, C.
    Tan, D.
    Oliver, B.
    Price, Patricia
    Waterer, G.
    Date
    2010
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Lim, A. and Allison, C. and Tan, D. and Oliver, B. and Price, P. and Waterer, G. 2010. Immunological markers of lung disease due to non-tuberculous mycobacteria. Disease Markers. 29 (2): pp. 103-109.
    Source Title
    Disease Markers
    DOI
    10.3233/DMA-2010-0732
    ISSN
    0278-0240
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/16224
    Collection
    • Curtin Research Publications
    Abstract

    Lung disease due to non-tuberculous mycobacteria (NTM) is a poorly understood condition that is difficult to treat. Treatment remains problematic as few tools are available to help clinicians monitor disease progression or predict treatment outcome. In this study, plasma levels of several inflammatory molecules and the frequency of circulating T cell subsets were measured in patients with NTM lung disease and known treatment status, and compared with their adult offspring and with unrelated healthy controls. Plasma levels of the chemokine CXCL10 and IL-18 were assessed for associations with treatment efficacy. CXCL10 was higher in patients than adult offspring (p< 0.001) and unrelated controls (p< 0.001). Plasma CXCL10 was also lower in patients who responded well to therapy or who controlled their infection without requiring therapy, when compared to patients who did not respond to therapy (p=0.03). Frequencies of activated (HLA-DR +) CD4 + T cells were higher in patients than adult offspring (p<0.001) and unrelated controls (p<0.05), with the highest frequencies in individuals who had completed at least 6 months of treatment. Frequencies of activated (CD38 +) CD8 + T cells in most treatment responders were similar to unrelated controls. Low plasma levels of CXCL10 may reflect successful control of NTM lung disease with or without therapy. Compared with responders, patients who responded poorly to treatment generally had higher plasma levels of CXCL10 and IL-18, and higher frequencies of activated CD8 + T cells. © 2010 - IOS Press and the authors. All rights reserved.

    Related items

    Showing items related by title, author, creator and subject.

    • A longitudinal study of the effects of ART on plasma chemokine levels in Malaysian HIV patients
      Chew, C.; Cherry, C.; Kamarulzaman, A.; Yien, T.; Aghafar, Z.; Price, Patricia (2011)
      Objectives: Chemokines influence the migration of leukocytes to secondary lymphoid tissue and sites of inflammation. In HIV patients, they are implicated in inflammatory complications of antiretroviral therapy (ART), ...
    • Mediators of innate and adaptive immune responses differentially affect immune restoration disease associated with Mycobacterium tuberculosis in HIV patients beginning antiretroviral therapy
      Oliver, B.; Elliott, J.; Price, Patricia; Phillips, M.; Saphonn, V.; Vun, M.; Kaldor, J.; Cooper, D.; French, M. (2010)
      Background. Initiation of antiretroviral therapy (ART) in human immunodeficiency virus patients with treated or unrecognized Mycobacterium tuberculosis infection may result in tuberculosis-associated immune reconstitution ...
    • Tuberculosis after commencing antiretroviral therapy for HIV infection is associated with elevated CXCL9 and CXCL10 responses to Mycobacterium tuberculosis antigens.
      Oliver, B.; Elliott, J.; Price, Patricia; Phillips, M.; Cooper, D.; French, M. (2012)
      Background: Commencing antiretroviral therapy (ART) in human immunodeficiency virus-infected patients with treated or unrecognized Mycobacterium tuberculosis disease may trigger tuberculosis-associated immune reconstitution ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.