Exposure to Pesticides and the Risk of Childhood Brain Tumors
|dc.contributor.author||de Klerk, N.|
|dc.identifier.citation||Greenop, K. and Peters, S. and Bailey, H. and Fritschi, L. and Attia, J. and Scott, R. and Glass, D. et al. 2013. Exposure to Pesticides and the Risk of Childhood Brain Tumors. Cancer Causes and Control. 24: pp. 1269-1278.|
Purpose Previous research has suggested positive associations between parental or childhood exposure to pesticides and risk of childhood brain tumors (CBT). This Australian case–control study of CBT investigated whether exposures to pesticides before pregnancy, during pregnancy and duringchildhood, were associated with an increased risk.Methods Cases were recruited from 10 pediatric oncology centers, and controls by random-digit dialing, frequency matched on age, sex, and State of residence. Exposure data were collected by written questionnaires and telephone interviews. Data were analyzed by unconditional logistic regression.Results The odds ratios (ORs) for professional pest control treatments in the home in the year before the index pregnancy, during the pregnancy, and after the child’s birth were 1.54 (95 % confidence interval (CI): 1.07, 2.22), 1.52 (95 % CI: 0.99, 2.34) and 1.04 (95 % CI: 0.75, 1.43), respectively. ORs for treatments exclusively before pregnancy and during pregnancy were 1.90 (95 % CI: 1.08, 3.36) and 1.02 (95 % CI: 0.35, 3.00), respectively. The OR for the father being home during the treatment was 1.79(95 % CI: 0.85, 3.80). The OR for paternal occupational exposure in the year before the child’s conception was 1.36 (95 % CI: 0.66, 2.80). ORs for prenatal home pesticide exposure were elevated for low- and high-grade gliomas; effect estimates for other CBT subtypes varied and lacked precision.Conclusions These results suggest that preconception pesticide exposure, and possibly exposure during pregnancy, is associated with an increased CBT risk. It may be advisable for both parents to avoid pesticide exposure during this time.
|dc.publisher||Kluwer Academic Publishers|
|dc.title||Exposure to Pesticides and the Risk of Childhood Brain Tumors|
|dcterms.source.title||Cancer Causes and Control|
|curtin.accessStatus||Fulltext not available|