Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2-amines.

dc.contributor.author	Dolzhenko, Anton
dc.contributor.author	Chui, W.
dc.date.accessioned	2017-01-30T11:56:26Z
dc.date.available	2017-01-30T11:56:26Z
dc.date.created	2011-08-22T20:01:18Z
dc.date.issued	2007
dc.identifier.citation	Dolzhenko, Anton and Chui, Wai. 2007. Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2-amines. Pharmaceutical Chemistry Journal. 41 (9): pp. 470-473.
dc.identifier.uri	http://hdl.handle.net/20.500.11937/16544
dc.identifier.doi	10.1007/s11094-007-0103-5
dc.description.abstract	Several 4-substituted 1,3,5-triazino[1,2-a]benzimidazol-2-amines were prepared via cyclization of 2-benzimidazolylguanidine with various reactants. The prototropic tautomerism in the obtained dihydro analogs was investigated. According to the NMR data, the 3,4-dihydro form was found to predominate in DMSO solutions. All tested compounds inhibited the activity of mammalian dihydrofolate reductase. The most active compound was 4,4-dimethyl-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazol-2-amine (IC50 = 10.9 microM).
dc.publisher	Springer
dc.title	Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2-amines.
dc.type	Journal Article
dcterms.source.volume	41
dcterms.source.number	9
dcterms.source.startPage	470
dcterms.source.endPage	473
dcterms.source.issn	0091-150X
dcterms.source.title	Pharmaceutical Chemistry Journal
curtin.department	School of Pharmacy
curtin.accessStatus	Fulltext not available