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dc.contributor.authorSutalo, Iiija
dc.contributor.authorBui, A.
dc.contributor.authorLiffman, Kurt
dc.contributor.authorManasseh, R.
dc.contributor.editorC.A. Brebbia, M. Eglite, I. Knets, R. Miftahof and V. Popov
dc.identifier.citationSutalo, I.J. and Bui, A. and Liffman, K. and Manasseh, R. 2011. Modelling of embolus transport and embolic stroke, in C.A. Brebbia, M. Eglite, I. Knets, R. Miftahof and V. Popov (ed), Environmental Health & Biomedicine, pp. 347-358. Southampton, UK: WIT Press.

Cerebral microembolism may lead to the restriction of blood supply due to damaged blood vessel tissue (focal ischemia) which is increasingly seen as the cause of cognitive deterioration including Alzheimer’s disease and vascular dementia.The flow through fractal models of the peripheral vasculature of the Anterior Cerebral Arteries (ACA) and Middle Cerebral Arteries (MCA) was modelled.The multi-scale model of the cerebral vasculature was coupled with blood flow and embolus transport models.The model incorporated asymmetric bifurcation trees, embolus-vascular interactions and autoregulation.Simulations were carried out where the embolus deposition rate, embolus diameter and embolus introduction rate were varied.Increasing the embolus diameter and embolus introduction rate increased the number of blocked terminal arteries to a quasi steady-state.For a low embolus deposition rate the MCA and ACA territory had the same embolization dynamics, even though, the MCA was larger than the ACA.It was also found for a higher embolus deposition rate the MCA, due to its more expansive structure, was less prone to occlusion than the ACA. The results also showed the effect of a single blockage is expected to be less severe in asymmetric flow than symmetric flow.

dc.publisherWIT Press
dc.subjectdamaged blood vessel tissue
dc.subjectcognitive deterioration
dc.subjectasymmetric bifurcation trees
dc.subjectembolus transport models
dc.subjectvascular dementia
dc.subjectAlzheimer’s disease
dc.subjectembolus-vascular interactions
dc.subjectCerebral microembolism
dc.subjectMiddle Cerebral Arteries (MCA)
dc.subjectAnterior Cerebral Arteries (ACA)
dc.subjectcerebral vasculature
dc.titleModelling of embolus transport and embolic stroke
dc.typeBook Chapter
dcterms.source.titleEnvironmental Health & Biomedicine
dcterms.source.placeSouthampton, UK
curtin.accessStatusFulltext not available

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