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    CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or ? d T-cells, in HIV patients responding to ART

    Access Status
    Open access via publisher
    Authors
    Tanaskovic, S.
    Fernandez, S.
    Price, Patricia
    Lee, S.
    French, M.
    Date
    2010
    Type
    Journal Article
    
    Metadata
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    Abstract

    Some severely immunodeficient HIV patients experience poor recovery of CD4 T-cell counts on antiretroviral therapy (ART). Evaluation of the function of thymopoiesis in T-cell production in individual patients requires a simple marker of T-cells that have recently emigrated from the thymus. Here, we address whether expression of CD31 on CD4 T-cells, CD8 T-cells, regulatory T-cells and ? T-cells correlates with other indicators of thymus function. Adult HIV-1 patients (n27) with nadir CD4 T-cell counts 100 per l and a sustained virological response to ART and healthy controls (n23) were studied. CD31 expression was assessed by flow cytometry, T-cell receptor excision circles content by real-time PCR and thymic volume by spiral computed tomography. Proportions of CD4 T-cells expressing CD45RA and CD31 declined with age in HIV patients (P0.03) and healthy controls (P0.0001), and correlated directly with other markers of thymus function. In controls, proportions of CD8 T-cells expressing CD45RA and CD31 declined with age (P0.003) and correlated directly with some markers of thymus function, but this was not seen in HIV patients. Proportions of CD45RA CD31 ? T-cells were higher in patients than controls (P0.007) and did not correlate with thymus volume. In controls, proportion of ? T-cells co-expressing CD45RA and CD31 increased with age (P0.002). These data support the use of CD31 as a marker of recent thymic origin in CD4 T-cells, but not CD8 T-cells in HIV patients receiving ART. In such patients, CD31 expression is unlikely to indicate thymic origin in ? T-cells. © 2010 Australasian Society for Immunology Inc. All rights reserved.

    Citation
    Tanaskovic, S. and Fernandez, S. and Price, P. and Lee, S. and French, M. 2010. CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or ? d T-cells, in HIV patients responding to ART. Immunology and Cell Biology. 88 (3): pp. 321-327.
    Source Title
    Immunology and Cell Biology
    DOI
    10.1038/icb.2009.108
    ISSN
    0818-9641
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/17404
    Collection
    • Curtin Research Publications

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