From a4ß2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design
dc.contributor.author | Yu, L. | |
dc.contributor.author | Zhang, H. | |
dc.contributor.author | Gunosewoyo, Hendra | |
dc.contributor.author | Kozikowski, A. | |
dc.date.accessioned | 2017-01-30T12:01:59Z | |
dc.date.available | 2017-01-30T12:01:59Z | |
dc.date.created | 2014-02-16T20:00:22Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Yu, Li-Fang and Zhang, Han-Kun and Gunosewoyo, Hendra and Kozikowski, Alan P. 2012. From a4ß2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design. ACS Medicinal Chemistry Letters. 3 (12): pp. 1054-1058. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/17442 | |
dc.identifier.doi | 10.1021/ml3002715 | |
dc.description.abstract |
Comparative analyses of the pharmacophoric elements required for σ1 and nicotinic ligands led to the identification of a potent and selective σ1 ligand (15). Compound 15 displayed high selectivity for the σ1 receptor (Ki, σ1 = 4.1 nM; Ki, σ2 = 1312 nM) with moderate binding affinity for the DAT (Ki = 373 nM) and NET (Ki = 203 nM) in the PDSP broad screening panel of common CNS neurotransmitter transporters and receptors. The key finding in this present work is that a subtle structural modification could be used as a tool to switch a ligand’s selectivity between nAChRs and sigma receptors. | |
dc.publisher | American Chemical Society | |
dc.subject | broad screening | |
dc.subject | sigma-1 receptor | |
dc.subject | alkoxyisoxazole | |
dc.subject | Nicotinic acetylcholine receptor | |
dc.subject | pharmacophore | |
dc.title | From a4ß2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design | |
dc.type | Journal Article | |
dcterms.source.volume | 3 | |
dcterms.source.startPage | 1054 | |
dcterms.source.endPage | 1058 | |
dcterms.source.issn | 1948-5875 | |
dcterms.source.title | ACS Medicinal Chemistry Letters | |
curtin.department | ||
curtin.accessStatus | Fulltext not available |