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dc.contributor.authorHennessy, E.
dc.contributor.authorAdams, C.
dc.contributor.authorReen, F.
dc.contributor.authorO'Gara, Fergal
dc.date.accessioned2017-01-30T12:02:23Z
dc.date.available2017-01-30T12:02:23Z
dc.date.created2016-09-20T19:30:19Z
dc.date.issued2016
dc.identifier.citationHennessy, E. and Adams, C. and Reen, F. and O'Gara, F. 2016. Is there potential for repurposing statins as novel antimicrobials?. Antimicrobial Agents and Chemotherapy. 60 (9): pp. 5111-5121.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/17526
dc.identifier.doi10.1128/AAC.00192-16
dc.description.abstract

Copyright © 2016, American Society for Microbiology. All Rights Reserved.Statins are members of a class of pharmaceutical widely used to reduce high levels of serum cholesterol. In addition, statins have so-called "pleiotropic effects," which include inflammation reduction, immunomodulation, and antimicrobial effects. An increasing number of studies are emerging which detail the attenuation of bacterial growth and in vitro and in vivo virulence by statin treatment. In this review, we describe the current information available concerning the effects of statins on bacterial infections and provide insight regarding the potential use of these compounds as antimicrobial therapeutic agents.

dc.publisherAmerican Society for Microbiology
dc.titleIs there potential for repurposing statins as novel antimicrobials?
dc.typeJournal Article
dcterms.source.volume60
dcterms.source.number9
dcterms.source.startPage5111
dcterms.source.endPage5121
dcterms.source.issn0066-4804
dcterms.source.titleAntimicrobial Agents and Chemotherapy
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher


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