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    A Rapid Test for Heroin (3,6-Diacetylmorphine) Based on Two Chemiluminescence Reactions

    Access Status
    Fulltext not available
    Authors
    Agg, K.
    Craddock, A.
    Bos, R.
    Francis, P.
    Lewis, Simon
    Barnett, N.
    Date
    2006
    Type
    Journal Article
    
    Metadata
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    Citation
    Agg, K and Craddock, Adrian and Bos, Richard and Francis, Paul and Lewis, Simon and Barnett, Neil. 2006. A Rapid Test for Heroin (3,6-Diacetylmorphine) Based on Two Chemiluminescence Reactions. Journal of Forensic Sciences 51 (5): 1080-1084.
    Source Title
    Journal of Forensic Sciences
    DOI
    10.1111/j.1556-4029.2006.00215.x
    Faculty
    Division of Engineering, Science and Computing
    Faculty of Science
    School
    Department of Applied Chemistry
    URI
    http://hdl.handle.net/20.500.11937/17815
    Collection
    • Curtin Research Publications
    Abstract

    A rapid method for screening drug seizure samples for 3,6-diacetylmorphine (heroin), which consists of a simple hydrolysis procedure and flow-injection analysis with two chemiluminescence reagents, is described. Before hydrolysis, 3,6-diacetylmorphine evokes an intense response with a tris(2,20-bipyridyl)ruthenium(III) reagent (prepared by dissolving the perchlorate salt in acetonitrile), and a relatively weak chemiluminescence response with a second reagent: potassium permanganate in an aqueous acidic polyphosphate solution. However, the permanganate reagent is extremely sensitive toward the hydrolysis products of 3,6-diacetylmorphine (i.e., 6-monoacetylmorphine and morphine). Some compounds commonly found in drug laboratories may cause false positives with tris(2,20-bipyridyl)ruthenium(III), but do not produce the markedly increased response with the permanganate reagent after the hydrolysis procedure. The combination of these two tests therefore provides an effective presumptive test for the presence of 3,6-diacetylmorphine, which we have verified with 14 samples obtained from a forensic science laboratory.

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