Value of Pathology Review in a Population-based Series of Ovarian Tumors
MetadataShow full item record
Ovarian neoplasia comprises a heterogenous group of tumors with distinct clinicopathologic and molecular features and therefore assessment of potential risk factors should be tumor subtype specific. As part of ongoing epidemiological investigations of ovarian neoplasia in Western Australia, we performed an initial review of original pathology reports followed, in selected cases, by reassessment of histology material to optimize accurate diagnosis. Additional immunohistochemistry, often using antibodies unavailable at the time of initial assessment, was also performed as required. From an initial cohort of 1660 cases identified through the Western Australia Cancer Registry, benign, nonepithelial, nonovarian, miscellaneous, and indeterminate cases were excluded. Also excluded were 33 cases that were reclassified as ovarian metastases rather than primary ovarian tumors. Following exclusions there remained 1321 borderline and malignant epithelial neoplasms. The diagnosis was considered accurate in 1186 cases (89.8%) based upon information in the initial pathology reports and clinical follow-up data but uncertain in 135 cases (10.2%). Histologic review was possible in 92 of the latter tumors leading to an amended diagnosis in 63 cases (68.5%). The most common types of diagnostic amendment were the reclassification of high-grade carcinomas of undifferentiated, endometrioid, or transitional appearance as high-grade serous carcinoma, and the reclassification of most carcinomas of mixed epithelial type as “pure” carcinomas. This review illustrated specific pitfalls in the diagnosis of ovarian epithelial neoplasia and helped to maintain the accuracy of the Western Australia Cancer Registry. Accurate diagnosis will optimize further epidemiological studies assessing risk factors in specific subtypes of ovarian neoplasia.
This is a non-final version of an article published in final form in International Journal of Gynecological Pathology. doi: 10.1097/PGP.0000000000000342
Showing items related by title, author, creator and subject.
Risk of high-grade cervical dysplasia and gynaecological malignancies following the cytologic diagnosis of atypical endocervical cells of undetermined significance: A retrospective study of a state-wide screening population in Western AustraliaMunro, A.; Williams, Vincent; Semmens, James; Leung, Y.; Stewart, C.; Codde, Jim; Spilsbury, Katrina; Steel, N.; Cohen, P.; O'Leary, Peter (2015)Background: In 2006, Australia adopted a revised cervical cytology terminology system, known as the Australian Modified Bethesda System (AMBS). One substantial change in the AMBS was the introduction of the diagnostic ...
Raftopoulos, S.; Kumarasinghe, P.; de Boer, B.; Iacobelli, J.; Kontorinis, N.; Fermoyle, S.; Olynyk, John; Forrest, C.; Ee, H.; Yusoff, I. (2012)Background and study aims: Descriptions of the natural history and endoscopic appearances of gastric dysplasia/ intraepithelial neoplasia (IEN) that originate mainly from Europe. Currently, there are no Australian data ...
Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological marginsMunro, A.; Codde, J.; Spilsbury, Katrina; Stewart, C.; Steel, N.; Leung, Y.; Tan, J.; Salfinger, S.; Mohan, G.; Semmens, James; Cohen, P. (2017)INTRODUCTION: Conservative treatments including cold knife cone biopsy (CKC) or loop electrosurgical excision procedure (LEEP) are fertility-preserving alternatives to hysterectomy. The risks of persistent cervical neoplasia ...