Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Longitudinal bone mineral content and density in Rett syndrome and their contributing factors

    Access Status
    Fulltext not available
    Authors
    Jefferson, Amanda
    Fyfe, Sue
    Downs, Jennepher
    Woodhead, H.
    Jacoby, P.
    Leonard, H.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Jefferson, A. and Fyfe, S. and Downs, J. and Woodhead, H. and Jacoby, P. and Leonard, H. 2015. Longitudinal bone mineral content and density in Rett syndrome and their contributing factors. Bone. 74: pp. 191-198.
    Source Title
    Bone
    DOI
    10.1016/j.bone.2015.01.023
    ISSN
    8756-3282
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/17825
    Collection
    • Curtin Research Publications
    Abstract

    Bone mass and density are low in females with Rett syndrome. This study used Dual energy x-ray absorptiometry to measure annual changes in z-scores for areal bone mineral density (aBMD) and bone mineral content (BMC) in the lumbar spine and total body in an Australian Rett syndrome cohort at baseline and then after three to four years. Bone mineral apparent density (BMAD) was calculated in the lumbar spine. Annual changes in lean tissue mass (LTM) and bone area (BA) were also assessed. The effects of age, genotype, mobility, menstrual status and epilepsy diagnosis on these parameters were also investigated. The baseline sample included 97 individuals who were representative of the total live Australian Rett syndrome population under 30 years in 2005 (n = 274). Of these 74 had a follow-up scan. Less than a quarter of females were able to walk on their own at follow-up. Bone area and LTM z-scores declined over the time between the baseline and follow-up scans. Mean height-standardised z-scores for the bone outcomes were obtained from multiple regression models. The lumbar spine showed a positive mean annual BMAD z-score change (0.08) and a marginal decrease in aBMD (− 0.04). The mean z-score change per annum for those ‘who could walk unaided’ was more positive for LS BMAD (p = 0.040). Total body BMD mean annual z-score change from baseline to follow-up was negative (− 0.03). However this change was positive in those who had achieved menses prior to the study (0.03, p = 0,040). Total body BMC showed the most negative change (− 0.60), representing a decrease in bone mineral content over time. This normalised to a z-score change of 0.21 once adjusted for the reduced lean tissue mass mean z-score change (− 0.21) and bone area mean z-score change (− 0.14).Overall, the bone mineral content, bone mineral density, bone area and lean tissue mass z-scores for all outcome measures declined, with the TB BMC showing significant decreases. Weight, height and muscle mass appear to have impacts on bone formation and we recommend that nutritional intake should be closely monitored and a physical activity plan developed to optimise bone health. Pubertal progression should also be assessed in conjunction with serial densitometry assessments to track bone mass and density changes over time.

    Related items

    Showing items related by title, author, creator and subject.

    • Bone Mineral Changes in Epilepsy Patients During Initial Years of Antiepileptic Drug Therapy
      Shiek Ahmad, B.; O'Brien, T.; Gorelik, A.; Hill, Keith; Wark, J. (2016)
      Antiepileptic drug (AED) therapy is associated with decreased bone mineral density; however, the time course for this development is unclear. The aim of this study was to evaluate bone mineral changes during the initial ...
    • Bone loss with antiepileptic drug therapy: a twin and sibling study
      Shiek Ahmad, B.; Petty, S.; Gorelik, A.; O Brien, T.; Hill, Keith; Christie, J.; Sambrook, P.; Wark, J. (2017)
      © 2017 International Osteoporosis Foundation and National Osteoporosis FoundationSummary: Changes in areal bone mineral density (aBMD) and other predictors of bone loss were evaluated in 48 same-sex twin/age-matched sibling ...
    • Peripheral quantitative computed tomography (pQCT) reveals low bone mineral density in adolescents with motor difficulties
      Hands, B.; Chivers, P.; McIntyre, F.; Bervenotti, F.; Blee, Tanya; Beeson, B.; Bettenay, F.; Siafarikas, A. (2015)
      © 2015, International Osteoporosis Foundation and National Osteoporosis Foundation. Summary: This is the first reported study to describe local bone mineral density, assess parameters of fracture risk and report history ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.