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dc.contributor.authorLewis, J.
dc.contributor.authorLim, W.
dc.contributor.authorZhu, K.
dc.contributor.authorWong, G.
dc.contributor.authorDhaliwal, Satvinder
dc.contributor.authorLim, E.
dc.contributor.authorUeland, T.
dc.contributor.authorBollerslev, J.
dc.contributor.authorPrince, R.
dc.identifier.citationLewis, J. and Lim, W. and Zhu, K. and Wong, G. and Dhaliwal, S. and Lim, E. and Ueland, T. et al. 2014. Elevated Osteoprotegerin Predicts Declining Renal Function in Elderly Women: A 10-Year Prospective Cohort Study. American Journal of Neuroradiology. 39 (1): pp. 66-74.

Background: Elevated osteoprotegerin (OPG) levels are inversely correlated with creatinine clearance and end-stage renal disease in patients with diabetes, however its role in predicting decline in renal function and progression to a more advanced stage disease in the elderly general population is unknown. Methods: This was a prospective cohort study of 1,157 elderly women with serum OPG measured in 1998 and renal function estimated using serum creatinine and cystatin C-based estimated glomerular filtration rate (eGFR) at 5-yearly intervals. The primary objective of the study was to determine the relationship of circulating OPG levels with 5- and 10-year renal decline. Results: At baseline, participants with elevated OPG above the median (≥2.2 ng/ml) had a 5.0% lower CKD-EPI-creatinine and cystatin C eGFR compared to participants with lower OPG levels. In multivariable-adjusted linear regression models, elevated OPG levels at baseline were associated with greater 5- and 10-year decline in CKD-EPI-creatinine and cystatin C eGFR (-0.105, p = 0.002 and -0.104, p = 0.010, respectively). Elevated OPG at baseline was associated with increased 5- and 10-year risk of rapid renal decline (OR 2.13, 95% CI 1.33-3.43, p = 0.002 and OR 4.10, 95% CI 1.49-11.27, p = 0.006, respectively) and renal disease hospitalizations or deaths (HR 1.99, 95% CI 1.31-3.03, p = 0.001) after adjusting for known risk factors. Conclusion: Elevated OPG levels are associated with long-term renal dysfunction and may be provide a useful biomarker to predict the trajectory of renal decline in older women.

dc.publisherAmerican Society of Neuroradiology
dc.subjectRenal decline
dc.subjectEstimated glomerular filtration rate
dc.subjectCreatinine and cystatin C
dc.titleElevated Osteoprotegerin Predicts Declining Renal Function in Elderly Women: A 10-Year Prospective Cohort Study
dc.typeJournal Article
dcterms.source.titleAmerican Journal of Neuroradiology
curtin.accessStatusFulltext not available

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