P-selectin expression tracks cerebral atrophy in Mexican-Americans
dc.contributor.author | Kochunov, P. | |
dc.contributor.author | Glahn, D. | |
dc.contributor.author | Hong, L. | |
dc.contributor.author | Lancaster, J. | |
dc.contributor.author | Curran, J. | |
dc.contributor.author | Johnson, M. | |
dc.contributor.author | Winkler, A. | |
dc.contributor.author | Holcomb, H. | |
dc.contributor.author | Kent, J. | |
dc.contributor.author | Mitchell, B. | |
dc.contributor.author | Kochunov, V. | |
dc.contributor.author | Olvera, R. | |
dc.contributor.author | Cole, S. | |
dc.contributor.author | Dyer, T. | |
dc.contributor.author | Moses, Eric | |
dc.contributor.author | Goring, H. | |
dc.contributor.author | Almasy, L. | |
dc.contributor.author | Duggirala, R. | |
dc.contributor.author | Blangero, J. | |
dc.date.accessioned | 2017-01-30T12:04:56Z | |
dc.date.available | 2017-01-30T12:04:56Z | |
dc.date.created | 2016-01-20T20:00:35Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Kochunov, P. and Glahn, D. and Hong, L. and Lancaster, J. and Curran, J. and Johnson, M. and Winkler, A. et al. 2012. P-selectin expression tracks cerebral atrophy in Mexican-Americans. Frontiers in Genetics. 3: Article ID 65. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/17940 | |
dc.identifier.doi | 10.3389/fgene.2012.00065 | |
dc.description.abstract |
Background and Purpose: We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for 13 mRNA gene expression measures from P-selectin and 11 other genes located in 1q24 region and three magnetic resonance imaging derived indices of cerebral integrity. Methods: The subject pool consisted of 369 (219F; aged 28–85, average = 47.1 ± 12.7 years) normally aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among 13 leukocyte-based mRNA gene expressions and three whole-brain and regional measurements of cerebral integrity: cortical gray matter thickness, fractional anisotropy of cerebral white matter, and the volume of hyperintensive WM lesions. Results: From the 13 gene expressions, significant phenotypic correlations were only found for the P- and L-selectin expression levels. Increases in P-selectin expression levels tracked with decline in cerebral integrity while the opposite trend was observed for L-selectin expression. The correlations for the P-selectin expression were driven by shared genetic factors, while the correlations with L-selectin expression were due to shared environmental effects. Conclusion: This study demonstrated that P-selectin expression shared a significant variance with measurements of cerebral integrity and posits elevated P-selectin expression levels as a potential risk factor of hypertension-related cerebral atrophy. | |
dc.title | P-selectin expression tracks cerebral atrophy in Mexican-Americans | |
dc.type | Journal Article | |
dcterms.source.volume | 3 | |
dcterms.source.number | MAY | |
dcterms.source.title | Frontiers in Genetics | |
curtin.department | School of Biomedical Sciences | |
curtin.accessStatus | Open access via publisher |