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    The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers

    235914_235914.pdf (2.863Mb)
    Access Status
    Open access
    Authors
    Ong, C.
    Chong, P.
    McArt, D.
    Chan, J.
    Tan, H.
    Kumar, Alan Prem
    Chung, M.
    Clément, M.
    Soong, R.
    Van Schaeybroeck, S.
    Waugh, D.
    Johnston, P.
    Dunne, P.
    Salto-Tellez, M.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Ong, C. and Chong, P. and McArt, D. and Chan, J. and Tan, H. and Kumar, A.P. and Chung, M. et al. 2015. The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers. Oncotarget. 6 (14): pp. 12763-12773.
    Source Title
    Oncotarget
    School
    School of Biomedical Sciences
    Remarks

    This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by/3.0/

    URI
    http://hdl.handle.net/20.500.11937/18387
    Collection
    • Curtin Research Publications
    Abstract

    Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the Western world. It is becoming increasingly clear that CRC is a diverse disease, as exemplified by the identification of subgroups of CRC tumours that are driven by distinct biology. Recently, a number of studies have begun to define panels of diagnostically relevant markers to align patients into individual subgroups in an attempt to give information on prognosis and treatment response. We examined the immunohistochemical expression profile of 18 markers, each representing a putative role in cancer development, in 493 primary colorectal carcinomas using tissue microarrays. Through unsupervised clustering in stage II cancers, we identified two cluster groups that are broadly defined by inflammatory or immune-related factors (CD3, CD8, COX-2 and FOXP3) and stem-like factors (CD44, LGR5, SOX2, OCT4). The expression of the stem-like group markers was associated with a significantly worse prognosis compared to cases with lower expression. In addition, patients classified in the stem-like subgroup displayed a trend towards a benefit from adjuvant treatment. The biologically relevant and poor prognostic stem-like group could also be identified in early stage I cancers, suggesting a potential opportunity for the identification of aggressive tumors at a very early stage of the disease.

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