The association of vitamin D status with dyslipidaemia and biomarkers of endothelial cell activation in older Australians
MetadataShow full item record
© 2016 by the authors; licensee MDPI, Basel, Switzerland.Background/Aims: Vitamin D has been investigated for many non-skeletal effects. The objective of this study was to determine whether circulating lipids, systemic inflammation, and biomarkers of endothelial cell activation varied with the vitamin D status of older Australians. Methods: One hundred and one participants were proportionately and randomly sampled across tertiles of 25 hydroxy vitamin D (25(OH)D) from a larger cohort of free living older adults (T1 median = 97; T2 median = 74.5; T3 median = 56.8 nmol/L). Overnight fasting blood samples were assayed for 25(OH)D, parathyroid hormone (PTH), insulin, triacylglycerol (TAG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C). Markers of systemic inflammation (high sensitivity C-reactive protein (hsCRP), tumour necrosis factor-a (TNF-a)) and endothelial activation (hepatocyte growth factor (HGF), P-selectin and soluble vascular cell adhesion molecule (sVCAM), soluble intracellular adhesion molecule (sICAM)) were determined. A general linear model multivariate analysis with a backward elimination procedure was performed. Results: Eighty-three participants (48 women, 35 men), aged 65 ± 7.7 years, BMI 28 ± 4.5 kg/m2, with complete data were analyzed. The final parsimonious model controlled for age, gender, BMI, and McAuley’s index, but excluded season, medications, and PTH. There were significant differences across 25(OH)D tertiles in TC (T1 < T3, p = 0.003; T2 < T3, p = 0.001), LDL-C (T1 < T3, p = 0.005; T2 < T3, p = 0.001), TAG (T2 < T3, p = 0.026), HGF (T1 > T3, p = 0.009) and sVCAM (T1 > T3, P = 0.04). Conclusions: Higher vitamin D status may protect the endothelium through reduced dyslipidaemia and increased HGF.
This open access article is distributed under the Creative Commons license https://creativecommons.org/licenses/by/4.0/
Showing items related by title, author, creator and subject.
The relationship of maternal micronutrient intakes of Vitamin B12, vitamin B6, folate and calcium on intrauterine growth retardation and birth weight : a prospective cohort study of urban South Indian pregnant womenDwarkanath, Pratibha (2011)The period of intrauterine growth and development is one of the most vulnerable periods in the human life cycle. The weight of the infant at birth is a powerful predictor of infant growth and survival, and is ...
Despite small increments in vitamin D intake by Irish adults over a decade, strategic initiatives to fortify the food supply are neededBlack, Lucinda; Walton, J.; Flynn, A.; Cashman, K.; Kiely, M. (2015)Background: Food fortification could be an effective method of increasing vitamin D intakes and preventing deficiency with minimal risk of excessive dosing. Objective: Secular trends in vitamin D intakes were examined ...
Despite small increments in vitamin D intake by Irish adults over a decade, strategic initiatives to fortify the food supply are needed.Black, Lucinda; Walkton, J.; Flynn, A.; Cashman, K.; Kiely, M. (2015)Background: Food fortification could be an effective method of increasing vitamin D intakes and preventing deficiency with minimal risk of excessive dosing. Objective: Secular trends in vitamin D intakes were examined ...