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    Yeast as a model for studying Alzheimer's disease

    Access Status
    Open access via publisher
    Authors
    Bharadwaj, Prashant
    Martins, R.
    Macreadie, I.
    Date
    2010
    Type
    Journal Article
    
    Metadata
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    Citation
    Bharadwaj, P. and Martins, R. and Macreadie, I. 2010. Yeast as a model for studying Alzheimer's disease. FEMS Yeast Research. 10 (8): pp. 961-969.
    Source Title
    FEMS Yeast Research
    DOI
    10.1111/j.1567-1364.2010.00658.x
    ISSN
    1567-1356
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/18591
    Collection
    • Curtin Research Publications
    Abstract

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by acute cognitive decline. The AD brain is featured by extracellular senile amyloid plaques, intraneuronal neurofibrillary tangles and extensive neuronal cell loss in specific regions of the brain associated with memory. The exact mechanism of neuronal cell dysfunction leading to the memory loss in AD is poorly understood. A number of studies have indicated that yeast is a suitable model system to decipher the molecular mechanisms involved in a variety of neurodegenerative disorders caused by pathological protein misfolding and deposition. Here, the knowledge from various studies that have utilized a yeast model to study the mechanism of pathways involved in AD pathogenesis is summarized. © 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

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