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    Murray Valley encephalitis: a review of clinical features, diagnosis and treatment

    189903.pdf (369.3Kb)
    Access Status
    Open access
    Authors
    Knox, James
    Cowan, Raquel
    Doyle, Joseph
    Ligtermoet, Matthew
    Archer, John
    Burrow, James
    Tong, Steven
    Currie, Bart
    Mackenzie, John
    Smith, David
    Catton, Mike
    Moran, Rodney
    Aboltins, Craig
    Richards, Jack
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Knox, J. and Cowan, R. and Doyle, J. and Ligtermoet, M. and Archer, J. and Burrow, J. and Tong, S. et al. 2012. Murray Valley encephalitis: a review of clinical features, diagnosis and treatment. Medical Journal of Australia. 196 (5): pp. 322-326.
    Source Title
    Medical Journal of Australia
    DOI
    10.5694/mja11.11026
    ISSN
    0025 729X
    Remarks

    © Copyright 2012. The Medical Journal of Australia - reproduced with permission.

    URI
    http://hdl.handle.net/20.500.11937/18701
    Collection
    • Curtin Research Publications
    Abstract

    Murray Valley encephalitis virus (MVEV) is a mosquito-borne virus that is found across Australia, Papua New Guinea and Irian Jaya. MVEV is endemic to northern Australia and causes occasional outbreaks across south-eastern Australia. 2011 saw a dramatic increase in MVEV activity in endemic regions and the re-emergence of MVEV in south-eastern Australia. This followed significant regional flooding and increased numbers of the main mosquito vector, Culex annulirostris, and was evident from the widespread seroconversion of sentinel chickens, fatalities among horses and several cases in humans, resulting in least three deaths. The last major outbreak in Australia was in 1974, during which 58 cases were identified and the mortality rate was about 20%. With the potential for a further outbreak of MVEV in the 2011–2012 summer and following autumn, we highlight the importance of this disease, its clinical characteristics and radiological and laboratory features. We present a suspected but unproven case of MVEV infection to illustrate some of the challenges in clinical management. It remains difficult to establish an early diagnosis of MVEV infection, and there is a lack of proven therapeutic options.

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