Severe psychiatric disorders in mid-life and risk of dementia in late-life (age 65-84 years): A population based case-control study
MetadataShow full item record
Objective: To examine the association of mid-life exposure to several psychiatric disorders with the development of late-life dementia. Methods: A matched case-control study using Western Australian state-wide hospital inpatient, outpatient mental health and emergency records linked to death records. Incident dementia cases (2000-2009) aged 65 to 84 years were sex- and age-matched to an electoral roll control. Records as far back as 1970 were used to assess exposure to medical risk factors before age 65 years. Candidate psychiatric risk factors were required to be present at least 10 years before dementia onset to ensure direction of potential causality. Odds ratios were estimated using conditional logistic regression. Results: 13, 568 dementia cases (median age 78.7 years, 43.4 % male) were matched to a control. Depression, bipolar disorder, schizophrenia, anxiety disorder and alcohol dependence were found to be significant and independent risk factors for late-life dementia after adjusting for diabetes, heart disease, cerebrovascular disease and smoking risk factors. The effect of a history of depression, schizophrenia and alcohol dependency on dementia risk varied with age, being strongest for earlier onset late-life dementia and waning at older ages. Conclusion: Severe depression, anxiety disorder, bipolar disorder, schizophrenia and alcoholic dependency disorder treated by specialists in psychiatric facilities in mid-life are important risk factors for late-life dementia. These psychiatric conditions need to be considered in future studies of the risk and prevention of late-life dementia.
Showing items related by title, author, creator and subject.
A whole-of-population study of the prevalence and patterns of criminal offending in people with schizophrenia and other mental illnessMorgan, V.; Morgan, F.; Valuri, G.; Ferrante, Anna; Castle, D.; Jablensky, A. (2013)Background Large epidemiological studies are needed to better understand the prevalence and profile of offending by people with mental illness. This study used a whole-of-population design to examine the prevalence, type ...
Sexual function of women during the first year after childbirth: Effect of parity (giving birth after the 20th week of pregnancy), depression and relationship satisfactionKhajehei, Marjan (2013)The aim of the present study was to measure the effect of parity, relationship satisfaction and depression on the sexual function of postpartum women during the first year after childbirth. This was a cross-sectional ...
Xu, F.; Li, Z.; Binns, Colin; Bonello, M.; Austin, M.; Sullivan, E. (2014)Background: Breastfeeding has been reported to reduce the risk of postpartum anxiety and depression. However, little is known of the effects of breastfeeding on hospital admissions for postpartum mental disorders. Materials ...