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    The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep

    165387_40745_Review Article final pub.pdf (522.8Kb)
    Access Status
    Open access
    Authors
    Lee, C.
    Munyard, Kylie
    Gregg, Keith
    Wetherall, John
    Stear, M.
    Groth, David
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Lee, C.Y. and Munyard, K.A. and Gregg, K. and Wetherall, J.D. and Stear, M.J. and Groth, D.M. 2011. The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep. Journal of Parasitology Research.
    Source Title
    journal of Parasitology Research
    DOI
    10.1155/2011/101848
    ISSN
    20900023
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/18903
    Collection
    • Curtin Research Publications
    Abstract

    Gastrointestinal nematode parasites in farmed animals are of particular importance due to their effects on production. In Australia, it is estimated that the direct and indirect effects of parasite infestation cost the animal production industries hundreds of millions of dollars each year. The main factors considered by immunologists when studying gastrointestinal nematode infections are the effects the host's response has on the parasite, which immunological components are responsible for these effects, genetic factors involved in controlling immunological responses, and the interactions between these forming an interconnecting multilevel relationship. In this paper, we describe the roles of immunoglobulins, in particular IgA and IgE, and the major histocompatibility complex in resistance to gastrointestinal parasites in sheep. We also draw evidence from other animal models to support the involvement of these immune components. Finally, we examine how IgA and IgE exert their influence and how methods may be developed to manage susceptible animals.

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