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    Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor

    20859_downloaded_stream_315.pdf (159.9Kb)
    Access Status
    Open access
    Authors
    Xie, Ling
    Helmerhorst, Erik
    Plewright, Brian
    Van Bronswijk, Wilhelm
    Martins, R.
    Date
    2002
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Xie, Ling and Helmerhorst, Erik and Plewright, Brian and Van Bronswijk, Wilhelm and Martins, Ralph. 2002. Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor. The Journal of Neuroscience 22 (RC221): 1-5.
    Source Title
    The Journal of Neuroscience
    Additional URLs
    http://www.jneurosci.org/content/vol22/issue10/
    Faculty
    Division of Health Sciences
    School of Biomedical Sciences
    Remarks

    Copyright 2002 Society of Neuroscience

    Please refer to the publisher for the definitive published version.

    URI
    http://hdl.handle.net/20.500.11937/19003
    Collection
    • Curtin Research Publications
    Abstract

    The amyloid- (A) peptide is neurotoxic and associated with the pathology of Alzheimer's disease (AD). We investigated the effect of A peptides on insulin binding to the insulin receptor because it is known that (1) A and insulin are both amyloidogenic peptides sharing a common sequence recognition motif, (2) A and insulin are substrates for the same insulin degrading enzyme, and (3) impaired glucose metabolism is a characteristic event in the pathology of AD. We discovered that A1-40 and A1-42, the main physiological forms, reduced insulin binding and receptor autophosphorylation. The reduction in binding was caused by a decrease in the affinity of insulin binding to the insulin receptor. This reduction was independent of the receptor concentration. The reverse, control peptide A40-1 did not reduce insulin binding or insulin receptor autophosphorylation. These results demonstrate that A is a direct competitive inhibitor of insulin binding and action. We speculate that the increased levels of A in Alzheimer's disease may be linked to the associated insulin resistance that has been observed previously in this disease.

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