Inhalable curcumin formulations by supercritical technology
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Inhalable dry formulations for pulmonary delivery of curcumin have been produced by supercritical antisolvent micronization. The antioxidant curcumin was co-processed with hydroxypropyl-beta-cyclodextrin (HP-ß-CD) and polyvinylpyrrolidone (PVP) to form binary and ternary composites with enhanced flow-ability for pulmonary delivery. The micronization process adopted was the atomized rapid injection solvent extraction (ARISE) system, and was operated at 95 bar and at temperatures of 25 °C and 40 °C. The products were evaluated in terms of morphology, composition, crystallinity and aerodynamic particle size distributions. A synergistic effect of the excipients on the aerodynamic properties of micronized curcumin formulations has been found. The fine particle fraction (FPF) of curcumin in ARISE-processed powders was as high as 61% in ternary systems, whilst untreated curcumin had a FPF of 10% and micronized binary systems had FPF below 40%. The process produced yields of about 80%, demonstrating significant potential for further development of curcumin formulations for pulmonary administration.
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Kurniawansyan, F.; Duong, H.; Danh, L.; Mammucari, R.; Vittorio, O.; Boyer, C.; Foster, Neil (2015)Inhalable formulations of curcumin with hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone have been produced by a newly developed anti-solvent micronization technique based on the supercritical fluid (SCF) technology. ...
Kurniawansyah, F.; Mammucari, R.; Foster, Neil (2017)© 2016 Elsevier B.V. Within the group of dense gas micronization processes, batch processes are attractive for the relative ease and cost-effectiveness of their scale-up. However, process parameters and product characteristics ...
Kurniawansyah, F.; Quachie, L.; Mammucari, R.; Foster, Neil (2017)© 2017 Elsevier B.V. The dissolution properties of curcumin are notoriously poor and hinder its bioavailability. To improve its dissolution properties, curcumin has been formulated with methyl-ß-cyclodextrin and ...