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    Western environment/lifestyle is associated with increased genome methylation and decreased gene expression in Chinese immigrants living in Australia

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    Authors
    Zhang, Guicheng
    Wang, K.
    Schultz, E.
    Khoo, S.
    Zhang, X.
    Annamalay, A.
    Laing, I.
    Hales, B.
    Goldblatt, J.
    Le Souëf, P.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Zhang, G. and Wang, K. and Schultz, E. and Khoo, S. and Zhang, X. and Annamalay, A. and Laing, I. et al. 2015. Western environment/lifestyle is associated with increased genome methylation and decreased gene expression in Chinese immigrants living in Australia. Environmental and Molecular Mutagenesis. 57 (1): pp. 65-73.
    Source Title
    Environmental and Molecular Mutagenesis
    DOI
    10.1002/em.21989
    ISSN
    0893-6692
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/19061
    Collection
    • Curtin Research Publications
    Abstract

    Introduction: Several human diseases and conditions are disproportionally distributed in the world with a significant “Western-developed” vs. “Eastern-developing” gradient. Methods: We compared genome-wide DNA methylation of peripheral blood mononuclear cells in 25 newly arrived Chinese immigrants living in a Western environment for less than 6 months (“Newly arrived”) with 23 Chinese immigrants living in the Western environment for more than two years (“Long-term”) with a mean of 8.7 years, using the Infinium HumanMethylation450 BeadChip. In a sub-group of both subject groups (n = 12 each) we also investigated genome-wide gene expression using a Human HT-12 v4 expression beadChip. Results: There were 62.5% probes among the total number of 382,250 valid CpG sites with greater mean Beta (β) in “Long-term” than in “Newly arrived”. In the regions of CpG islands and gene promoters, compared with the CpG sites in all other regions, lower percentages of CpG sites with mean methylation levels in “Long-term” greater than “Newly arrived” were observed, but still >50%. The increase of methylation was associated with a general decrease of gene expression in Chinese immigrants living in the Western environment for a longer period of time. After adjusting for age, gender and other confounding factors the findings remained. Conclusion: Chinese immigrants living in Australia for a longer period of time have increased overall genome methylation and decreased overall gene expression compared with newly arrived immigrants.

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