Western environment/lifestyle is associated with increased genome methylation and decreased gene expression in Chinese immigrants living in Australia
MetadataShow full item record
Introduction: Several human diseases and conditions are disproportionally distributed in the world with a significant “Western-developed” vs. “Eastern-developing” gradient. Methods: We compared genome-wide DNA methylation of peripheral blood mononuclear cells in 25 newly arrived Chinese immigrants living in a Western environment for less than 6 months (“Newly arrived”) with 23 Chinese immigrants living in the Western environment for more than two years (“Long-term”) with a mean of 8.7 years, using the Infinium HumanMethylation450 BeadChip. In a sub-group of both subject groups (n = 12 each) we also investigated genome-wide gene expression using a Human HT-12 v4 expression beadChip. Results: There were 62.5% probes among the total number of 382,250 valid CpG sites with greater mean Beta (β) in “Long-term” than in “Newly arrived”. In the regions of CpG islands and gene promoters, compared with the CpG sites in all other regions, lower percentages of CpG sites with mean methylation levels in “Long-term” greater than “Newly arrived” were observed, but still >50%. The increase of methylation was associated with a general decrease of gene expression in Chinese immigrants living in the Western environment for a longer period of time. After adjusting for age, gender and other confounding factors the findings remained. Conclusion: Chinese immigrants living in Australia for a longer period of time have increased overall genome methylation and decreased overall gene expression compared with newly arrived immigrants.
Showing items related by title, author, creator and subject.
Alcohol, tobacco and other drug concerns of newly arrived 'CaLD' (culturally and linguistically diverse) women in PerthLee, Susan Kaye (2008)Womens Health Services (WHS) in Perth provides medical services, counselling, information, community talks and workshops, referral, and outreach to women in Western Australia. WHS works with women from over sixty different ...
Molecular mechanism underlying aberrant expression of the connective tissue growth factor in paediatric pre-B cell acute lymphoblastic leukemiaWelch, Mathew D. (2011)Acute lymphoblastic leukaemia (ALL) is the most common cancer diagnosed in children aged 1-14 years. There have been vast improvements in clinical outcomes for children diagnosed with ALL with cure rates of up to 90% ...
Epigenetic regulation of the secreted frizzled-related protein family in human glioblastoma multiformeSchiefer, L.; Visweswaran, Malini; Perumal, Vanathi; Arfuso, Frank; Groth, David; Newsholme, Philip; Warrier, Sudha; Dharmarajan, Arunasalam (2014)Glioblastoma multiforme (GBM) are intracranial tumors of the central nervous system and the most lethal among solid tumors. Current therapy is palliative and is limited to surgical resection followed by radiation therapy ...