Fine tuning of protein kinase C (PKC) isoforms in cancer: Shortening the distance from the laboratory to the bedside
MetadataShow full item record
The serine/threonine protein kinase C (PKC) family was first identified as intracellular receptor(s) for the tumor promoting agents phorbol esters. Thirty years after the discovery of PKC, the role of specific PKC isoforms has been described in relationship with an altered pattern of expression in different types of cancer and a good number of small molecule inhibitors (inhibitory peptides, antisense oligonucleotides or natural compounds) targeting PKC are now available. Despite all these achievements and a huge amount of basic research studies on the biochemical regulation of PKC, there has been a delay in clinical trials with drugs targeting PKC function. This delay is easily explained taking into account the extreme biological complexity of the PKC family of isoforms and the incomplete understanding of the specific role of each PKC isozyme in different types of cancers. Some of the difficulties in developing pharmacological compounds selectively tuning the different PKCs have started to be overcome. In this review, the growing evidences of the role of the PKC isoforms α, βII, δ, , ζ and ι is in promoting or counteracting tumor progression will be discussed in relationship with promising therapeutic perspectives.
Showing items related by title, author, creator and subject.
Genome-level identification of cell wall invertase genes in wheat for the study of drought toleranceWebster, H.; Keeble, G.; Dell, B.; Fosu-Nyarko, J.; Mukai, Y.; Moolhuijzen, Paula; Bellgard, M.; Jia, J.; Kong, X.; Feuillet, C.; Choulet, F.; Appels, R. (2012)In wheat (Triticum aestivum L.) drought-induced pollen sterility is a major contributor to grain yield loss and is caused by the downregulation of the cell wall invertase gene IVR1. The IVR1 gene catalyses the irreversible ...
Identification and characterization of two novel and differentially expressed isoforms of human a2-and a1-globin genesGhassemifar, Reza; Forster, L.; Qadah, T.; Finlayson, J. (2012)In most references, the transcription initiation site for the a2-and a1-globin genes has been described to lie 37 bp upstream of the translation initiation codon, however, a review of data repositories such as GenBank and ...
Deleo, Domenica (1994)Prior to the commencement of this study in 1990, a number of reports had appeared in the literature describing the importance of insulin action during lactation in mammals (see Chapter 1). These studies investigated the ...