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    Fine tuning of protein kinase C (PKC) isoforms in cancer: Shortening the distance from the laboratory to the bedside

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    Fulltext not available
    Authors
    Bosco, R.
    Melloni, E.
    Celeghini, C.
    Rimondi, E.
    Vaccarezza, Mauro
    Zauli, G.
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Bosco, R. and Melloni, E. and Celeghini, C. and Rimondi, E. and Vaccarezza, M. and Zauli, G. 2011. Fine tuning of protein kinase C (PKC) isoforms in cancer: Shortening the distance from the laboratory to the bedside. Mini-Reviews in Medicinal Chemistry. 11 (3): pp. 185-199.
    Source Title
    Mini-Reviews in Medicinal Chemistry
    DOI
    10.2174/138955711795049899
    ISSN
    1389-5575
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/19080
    Collection
    • Curtin Research Publications
    Abstract

    The serine/threonine protein kinase C (PKC) family was first identified as intracellular receptor(s) for the tumor promoting agents phorbol esters. Thirty years after the discovery of PKC, the role of specific PKC isoforms has been described in relationship with an altered pattern of expression in different types of cancer and a good number of small molecule inhibitors (inhibitory peptides, antisense oligonucleotides or natural compounds) targeting PKC are now available. Despite all these achievements and a huge amount of basic research studies on the biochemical regulation of PKC, there has been a delay in clinical trials with drugs targeting PKC function. This delay is easily explained taking into account the extreme biological complexity of the PKC family of isoforms and the incomplete understanding of the specific role of each PKC isozyme in different types of cancers. Some of the difficulties in developing pharmacological compounds selectively tuning the different PKCs have started to be overcome. In this review, the growing evidences of the role of the PKC isoforms α, βII, δ, , ζ and ι is in promoting or counteracting tumor progression will be discussed in relationship with promising therapeutic perspectives.

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