Chitosan-benzofuran adduct for potential biomedical applications: Improved antibacterial and antifungal properties
MetadataShow full item record
Chitosan-benzofuran adduct showed better antifungal and antibacterial properties compared to chitosan or benzofuran alone. The new polymer hydrogel has been characterized using FTIR, SEM, DSC, TGA and XRD. FTIR proved the formation of Schiff’s base reaction at 1632 cm−1, between the chitosan’s amino group and the khellinone’s ketonic group. The X-ray diffraction patterns of chitosan-benzofuran showed the formation of a porous xerogel network. The TGA and DSC results were in accordance with the results obtained from the SEM. The TGA and DSC revealed slight loss in the chitosan-benzofuran’ thermal stability compared to chitosan hydrogel and that could be regarded to the increase in porosity as shown in the SEM. The novel chitosan-benzofuran hydrogel has shown an outstanding antifungal and antibacterial effect. Moreover, the cellular cytotoxicity of baby hamster kidney cells culture by adding different concentrations of chitosan-benzofuran hydrogel were greater than those obtained from benzofuran or chitosan alone as they were 4.81±2%, 5.27±2% and 9.43±5%, respectively.
Showing items related by title, author, creator and subject.
Elnashar, Magdy; Yassin, M. (2009)Lactose has been hydrolyzed using covalently immobilized ß-galactosidase on thermally stable carrageenan coated with chitosan (hydrogel). The hydrogel's mode of interaction was proven by Fourier transform infrared ...
Li, Chao (2012)The purpose of this dissertation was to synthesize and evaluate porous poly(2- hydroxyethyl methacrylate) (PHEMA) and PHEMA composite hydrogels containing various concentrations of titanium dioxide (TiO2) nanoparticles, ...
Injectable supramolecular hydrogel formed from a-cyclodextrin and PEGylated arginine-functionalized poly(L-lysine) dendron for sustained MMP-9 shRNA plasmid deliveryLin, Qun; Yang, Y.; Hu, Q.; Guo, Z.; Liu, T.; Xu, J.; Wu, J.; Kirk, T.; Ma, D.; Xue, W. (2017)© 2016 Acta Materialia Inc.Hydrogels have attracted much attention in cancer therapy and tissue engineering due to their sustained gene delivery ability. To obtain an injectable and high-efficiency gene delivery hydrogel, ...