Show simple item record

dc.contributor.authorDingjan, T.
dc.contributor.authorAgostino, M.
dc.contributor.authorRamsland, Paul
dc.contributor.authorYuriev, E.
dc.date.accessioned2017-01-30T12:12:25Z
dc.date.available2017-01-30T12:12:25Z
dc.date.created2015-11-04T04:24:24Z
dc.date.issued2015
dc.identifier.citationDingjan, T. and Agostino, M. and Ramsland, P. and Yuriev, E. 2015. Antibody-Carbohydrate Recognition from Docked Ensembles Using the AutoMap Procedure, in Lepenies, B. (ed), Carbohydrate-based Vaccines: Methods and Protocols, pp. 41-55. New York: Springer.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/19193
dc.identifier.doi10.1007/978-1-4939-2874-3_4
dc.description.abstract

Carbohydrate-protein recognition is vital to many processes in health and disease. In particular, elucidation of the structural basis of carbohydrate binding is important to the development of oligosaccharides and oligosaccharide mimetics as vaccines for infectious diseases and cancer. Computational structural techniques are valuable for the study of carbohydrate-protein recognition due to the challenges associated with experimental determination of carbohydrate-protein complexes. AutoMap is a computer program that we have developed to study protein-ligand recognition. AutoMap determines the interactions taking place in a set of highly ranked poses obtained from molecular docking and processes these to identify the protein residues most likely to be involved in interactions. In this protocol, we describe the use of AutoMap and illustrate its suitability for studying antibody recognition of the Lewis Y tetrasaccharide, which is a potential cancer vaccine antigen.

dc.titleAntibody-Carbohydrate Recognition from Docked Ensembles Using the AutoMap Procedure.
dc.typeJournal Article
dcterms.source.volume1331
dcterms.source.startPage41
dcterms.source.endPage55
dcterms.source.titleMethods Mol Biol
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record