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    Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: A Characterization Study

    200456_131449_Hani_Al_Salami_Drug_Design_Devel_and_Therapy_published_.pdf (5.122Mb)
    Access Status
    Open access
    Authors
    Mooranian, Armin
    Negrulj, Rebecca
    Chen-Tan, Nigel
    Al-Sallami, H.
    Fang, Zhongxiang
    Mukkur, Trilochan
    Mikov, Momir
    Golocorbin-Kon, S.
    Fakhoury, M.
    Arfuso, Frank
    Al-Salami, Hani
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Mooranian, A. and Negrulj, R. and Chen-Tan, N. and Al-Sallami, H. and Fang, Z. and Mukkur, T. and Mikov, M. et al. 2014. Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: A Characterization Study. Drug Design, Development and Therapy. (8): pp. 1003-1012.
    Source Title
    Drug Design, Development and Therapy
    DOI
    10.2147/DDDT.S65396
    ISSN
    1177-8881
    School
    School of Pharmacy
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons License http://creativecommons.org/licenses/by-nc/3.0/us/ Please refer to the licence to obtain terms for any further reuse or distribution of this work

    URI
    http://hdl.handle.net/20.500.11937/19308
    Collection
    • Curtin Research Publications
    Abstract

    Gliclazide (G) is an antidiabetic drug commonly used in type 2 diabetes. It has extrapancreatic hypoglycemic effects, which makes it a good candidate in type 1 diabetes (T1D). In previous studies, we have shown that a gliclazide-bile acid mixture exerted a hypoglycemic effect in a rat model of T1D. We have also shown that a gliclazide-deoxycholic acid (G-DCA) mixture resulted in better G permeation in vivo, but did not produce a hypoglycemic effect. In this study, we aimed to develop a novel microencapsulated formulation of G-DCA with uniform structure, which has the potential to enhance G pharmacokinetic and pharmacodynamic effects in our rat model of T1D. We also aimed to examine the effect that DCA will have when formulated with our new G microcapsules, in terms of morphology, structure, and excipients’ compatibility. Microencapsulation was carried out using the Büchi-based microencapsulating system developed in our laboratory. Using sodium alginate (SA) polymer, both formulations were prepared: G-SA (control) at a ratio of 1:30, and G-DCA-SA (test) at a ratio of 1:3:30. Complete characterization of microcapsules was carried out. The new G-DCA-SA formulation was further optimized by the addition of DCA, exhibiting pseudoplastic-thixotropic rheological characteristics. The size of microcapsules remained similar after DCA addition, and these microcapsules showed no chemical interactions between the excipients. This was supported further by the spectral and microscopy studies, suggesting microcapsule stability. The new microencapsulated formulation has good structural properties and may be useful for the oral delivery of G in T1D.

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