The safety of maternal immunization
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Maternal vaccination offers the opportunity to protect pregnant women and their infants against potentially serious disease. As both pregnant women and their newborns are vulnerable to severe illness, the potential public health impact of mass maternal vaccination programs is remarkable. Several high-income countries recommend seasonal influenza and acellular pertussis vaccines, and many developing countries recommend immunization against tetanus during pregnancy. There is a significant amount of literature supporting the safety of vaccination during pregnancy. As other vaccines are newly introduced for pregnant women, routine systems for monitoring vaccine safety in pregnant women are needed. To facilitate meta-analyses and comparison across systems and studies, future research and surveillance initiatives should utilize the same criteria for defining adverse events following immunization among pregnant women. At least 2 areas require further exploration: 1) identification of pregnancy outcomes associated with concomitant and closely spaced vaccines; 2) evaluation of possible improvement in birth outcomes associated with maternal vaccination. Given the public health impact of maternal vaccination, the existing evidence supporting the safety of vaccination during pregnancy should be used to reassure pregnant women and their providers and improve vaccine uptake in pregnancy.
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Safety of a killed oral cholera vaccine (Shanchol) in pregnant women in Malawi: an observational cohort studyAli, Mohammed; Nelson, A.; Luquero, F.; Azman, A.; Debes, A.; M'bang'ombe, M.; Seyama, L.; Kachale, E.; Zuze, K.; Malichi, D.; Zulu, F.; Msyamboza, K.; Kabuluzi, S.; Sack, D. (2017)© 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Background Pregnancy increases the risk of harmful effects from cholera for both mothers and their fetuses. A killed ...
Seasonal Trivalent Influenza Vaccination During Pregnancy and the Incidence of Stillbirth: Population-Based Retrospective Cohort StudyRegan, Annette; Moore, H.; de Klerk, N.; Omer, S.; Shellam, G.; Mak, D.; Effler, P. (2016)Background: Although antenatal influenza vaccination is an important public health intervention for preventing serious infection in pregnant women and newborns, reported vaccine coverage is often <50%. Concern for the ...
A prospective cohort study comparing the reactogenicity of trivalent influenza vaccine in pregnant and non-pregnant womenRegan, Annette; Tracey, L.; Blyth, C.; Mak, D.; Richmond, P.; Shellam, G.; Talbot, C.; Effler, P. (2015)Background: Influenza vaccination during pregnancy can prevent serious illness in expectant mothers and provide protection to newborns; however, historically uptake has been limited due to a number of factors, including ...