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dc.contributor.authorCarnagarin, Revathy
dc.contributor.authorDharmarajan, Arunasalam
dc.contributor.authorDass, Crispin
dc.date.accessioned2017-01-30T12:14:44Z
dc.date.available2017-01-30T12:14:44Z
dc.date.created2015-01-12T20:00:32Z
dc.date.issued2015
dc.identifier.citationCarnagarin, R. and Dharmarajan, A. and Dass, C. 2015. PEDF-induced alteration of metabolism leading to insulin resistance. Molecular and Cellular Endocrinology. 401: pp. 98-104.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/19606
dc.identifier.doi10.1016/j.mce.2014.11.006
dc.description.abstract

Pigment epithelium-derived factor (PEDF) is an anti-angiogenic, immunomodulatory, and neurotrophic serine protease inhibitor protein. PEDF is evolving as a novel metabolic regulatory protein that plays a causal role in insulin resistance. Insulin resistance is the central pathogenesis of metabolic disorders such as obesity, type 2 diabetes mellitus, polycystic ovarian disease, and metabolic syndrome, and PEDF is associated with them. The current evidence suggests that PEDF administration to animals induces insulin resistance, whereas neutralisation improves insulin sensitivity. Inflammation, lipolytic free fatty acid mobilisation, and mitochondrial dysfunction are the proposed mechanism of PEDF-mediated insulin resistance. This review summarises the probable mechanisms adopted by PEDF to induce insulin resistance, and identifies PEDF as a potential therapeutic target in ameliorating insulin resistance.

dc.publisherElsevier Ireland Ltd
dc.subjectObesity
dc.subjectPEDF
dc.subjectMetabolism
dc.subjectInsulin
dc.subjectDiabetes
dc.titlePEDF-induced alteration of metabolism leading to insulin resistance
dc.typeJournal Article
dcterms.source.volume401
dcterms.source.startPage98
dcterms.source.endPage104
dcterms.source.issn0303-7207
dcterms.source.titleMolecular and Cellular Endocrinology
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available


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