ASPREE-D: Aspirin for the prevention of depression in the elderly
MetadataShow full item record
This version of the article has been accepted for publication and will appear in a revised form subsequent to peer review and / or editorial input
Copyright © International Psychogeriatric Association 2016. Background:: Not only is depression associated with increased inflammation but inflammation is a risk factor for the genesis of depression. Many of the environmental risk factors for depression are transduced through inflammatory signaling. Anti-inflammatory agents show promise for the management of depression in preclinical, epidemiological, and early clinical studies. This opens the door to the potential for anti-inflammatory agents to treat and prevent depression. There are no evidence-based pharmacotherapies for depression prevention. Method:: ASPREE-D, aspirin in the prevention of depression in the elderly, is a sub study of ASPREE, which explores the potential of aspirin to prevent a range of inflammation related disorders in the elderly. With a sample size of 19,114, and a duration of 5 years, this placebo controlled study will be one of the largest randomized controlled trials in psychiatry and will provide definitive evidence on the ability of aspirin to prevent depression. Results:: This paper presents the rationale for the study and presents a summary of the study design. Conclusions:: ASPREE-D may not only define novel therapy but will provide mechanistic proof of concept of the role of inflammation in depression.
Showing items related by title, author, creator and subject.
Grimm, R.; McNeil, J.; Applegate, W.; Beilin, L.; Espinoza, S.; Johnston, C.; Kirpach, B.; Margolis, K.; Murray, A.; Nelson, M.; Reid, Christopher; Shah, R.; Storey, E.; Tonkin, A.; Wilson, P.; Wolfe, R.; Woods, R.; Abhayaratna, W.; Ames, D.; Cobiac, L.; Donnan, G.; Gibbs, P.; Head, R.; Krum, H.; Jelnik, M.; Malik, M.; Williamson, J.; Eaton, C.; Weissfeld, J.; MacRae, F.; Rodriguez, L.; Shah, R.; Newman, A.; Demons, J.; Workman, B.; Wood, E.; Satterfield, S.; Ernst, M.; Gilbertson, D.; Lockery, J.; Shah, R.; Ernst, M.; Hannah, J.; Newman, A.; Radziszewska, B.; Shah, R.; Thomas, A.; Gill, G.; Jackson, C.; Kidd, M.; Russell, G.; Pressman, G.; Figueredo, V.; Oberoi, M.; Ahmad, M.; Krstevska, S.; Lawson, C.; Katzman, S.; Powell, J.; Lang, M.; Bolin, P.; Atlanta, V.; Le, A.; Johnson, T.; Thomas, A.; Kruger, D.; Obisesan, T.; Allard, J.; Dodd, K.; Ott, B.; Pemu, P.; Radziszewska, B.; Hadley, E.; Romashkan, S.; Palaniappan, L.; Jose, P.; Church, T.; Myers, V.; Monce, R.; Britt, N.; Gupta, A.; Keller, J.; Shah, R.; Lewis, B.; Shikany, J.; Allman, R.; Anton, S.; Pahor, M.; Burns, J.; Swerdlow, R.; Anderson, H.; Wiggins, J.; Nyquist, L.; Peterson, K.; Newman, A.; Tindle, H.; Johnson, K.; Womack, C.; Birnbaum, L.; Nesbitt, S. (2013)Cost-effective strategies to maintain healthy active lifestyle in aging populations are required to address the global burden of age-related diseases. ASPREE will examine whether the potential primary prevention benefits ...
Age-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD studyRobman, L.; Guymer, R.; Woods, R.; Ward, S.; Wolfe, R.; Phung, J.; Hodgson, L.; Makeyeva, G.; Aung, K.; Gilbert, T.; Lockery, J.; Le-Pham, Y.; Orchard, S.; Storey, E.; Abhayaratna, W.; Reid, D.; Ernst, M.; Nelson, M.; Reid, Christopher; McNeil, J. (2017)Purpose: Although aspirin therapy is used widely in older adults for prevention of cardiovascular disease, its impact on the incidence, progression and severity of age-related macular degeneration (AMD) is uncertain. The ...
Slowing the progression of age-related hearing loss: Rationale and study design of the ASPIRIN in HEARING, retinal vessels imaging and neurocognition in older generations (ASPREE-HEARING) trialLowthian, J.; Britt, C.; Rance, G.; Lin, F.; Woods, R.; Wolfe, R.; Nelson, M.; Dillon, H.; Ward, S.; Reid, Christopher; Lockery, J.; Nguyen, T.; McNeil, J.; Storey, E. (2016)© 2015. Background: Age-related hearing loss (ARHL) is a leading cause of disability in the elderly. Low-grade inflammation and microvessel pathology may be responsible for initiating or exacerbating some of the hearing ...