Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS
dc.contributor.author | Reen, F. | |
dc.contributor.author | Clarke, S. | |
dc.contributor.author | Legendre, C. | |
dc.contributor.author | McSweeney, C. | |
dc.contributor.author | Eccles, K. | |
dc.contributor.author | Lawrence, S. | |
dc.contributor.author | O'Gara, Fergal | |
dc.contributor.author | McGlacken, G. | |
dc.date.accessioned | 2017-01-30T12:16:25Z | |
dc.date.available | 2017-01-30T12:16:25Z | |
dc.date.created | 2015-03-03T03:50:51Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Reen, F. and Clarke, S. and Legendre, C. and McSweeney, C. and Eccles, K. and Lawrence, S. and O'Gara, F. et al. 2012. Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS. Organic and Biomolecular Chemistry. 10 (44): pp. 8903-8910. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/19919 | |
dc.identifier.doi | 10.1039/c2ob26823j | |
dc.description.abstract |
2-Heptyl-3-hydroxy-4-quinolone (PQS) and its precursor 2-heptyl-4-quinolone (HHQ) are key signalling molecules of the important nosocomial pathogen Pseudomonas aeruginosa. We have recently reported an interkingdom dimension to these molecules, influencing key virulence traits in a broad spectrum of microbial species and in the human pathogenic yeast Candida albicans. For the first time, targeted chemical derivatisation of the C-3 position was undertaken to investigate the structural and molecular properties underpinning the biological activity of these compounds in P. aeruginosa, and using Bacillus subtilis as a suitable model system for investigating modulation of interspecies behaviour. | |
dc.publisher | Royal Society of Chemistry | |
dc.title | Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS | |
dc.type | Journal Article | |
dcterms.source.volume | 10 | |
dcterms.source.number | 44 | |
dcterms.source.startPage | 8903 | |
dcterms.source.endPage | 8910 | |
dcterms.source.issn | 1477-0520 | |
dcterms.source.title | Organic and Biomolecular Chemistry | |
curtin.accessStatus | Fulltext not available |
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