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    Treatment of chronic venous disease with flavonoids: Recommendations for treatment and further studies

    Access Status
    Fulltext not available
    Authors
    Rabe, E.
    Guex, J.
    Morrison, N.
    Ramelet, Anne-Sylvie
    Schuller-Petrovic, S.
    Scuderi, A.
    Staelens, I.
    Pannie, F.
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Rabe, E. and Guex, J. and Morrison, N. and Ramelet, A. and Schuller-Petrovic, S. and Scuderi, A. and Staelens, I. et al. 2013. Treatment of chronic venous disease with flavonoids: Recommendations for treatment and further studies. Phlebology. 28 (6): pp. 308-319.
    Source Title
    Phlebology
    DOI
    10.1177/0268355512471929
    ISSN
    0268-3555
    School
    School of Nursing and Midwifery
    URI
    http://hdl.handle.net/20.500.11937/19993
    Collection
    • Curtin Research Publications
    Abstract

    Objectives: Avariety of studies have suggested that flavonoids are effective for the treatment of CVD. However, many questions remain about their mechanism of action and when, how, and for what signs and symptoms they should be used. Method: A panel of experts in CVD met in Budapest, Hungary in December 2011 to discuss the current state of knowledge of CVD and the role of flavonoids in its treatment. The discussion was based on a literature search in the current databases. The goals of this paper are recommendations for further studies on the use of flavonoids in the treatment of CVD. Results: There is good evidence to recommend the use of flavonoids in the treatment of CVD. However, because of the poor quality of some older clinical trials, inadequate reporting, and insufficient information, much work is still needed to firmly establish their clinical efficacy and to determine when and how they should be employed. In particular, long-term randomized, placebo-controlled, double-blind studies are needed to establish the efficacy and safety of flavonoids. Additional studies are also needed to establish their mechanism of action, pharmacokinetics, toxicity, and cost-effectiveness. Conclusions: Aside from good evidence for the use of flavonoids in CVD further studies are indicated to establish long term treatment in this indication.

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