Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Predicting survival in malignant mesothelioma

    Access Status
    Open access via publisher
    Authors
    Musk, A.
    Olsen, N.
    Alfonso, Helman
    Reid, Alison
    Mina, R.
    Franklin, P.
    Sleith, J.
    Hammond, N.
    Threlfall, T.
    Shilkin, K.
    De Klerk, N.
    Date
    2011
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Musk, A. and Olsen, N. and Alfonso, H. and Reid, A. and Mina, R. and Franklin, P. and Sleith, J. et al. 2011. Predicting survival in malignant mesothelioma. European Respiratory Journal. 38 (6): pp. 1420-1424.
    Source Title
    European Respiratory Journal
    DOI
    10.1183/09031936.00000811
    ISSN
    0903-1936
    School
    Epidemiology and Biostatistics
    URI
    http://hdl.handle.net/20.500.11937/20002
    Collection
    • Curtin Research Publications
    Abstract

    Malignant mesothelioma (MM) of the pleura or peritoneum is a universally fatal disease attracting an increasing range of medical interventions and escalating healthcare costs. Changes in survival and the factors affecting survival of all patients ever diagnosed with MM in Western Australia over the past five decades and confirmed by the Western Australian Mesothelioma Registry to December 2005 were examined. Sex, age, date and method of diagnosis, site of disease and histological type were recorded. Date of onset of symptoms and performance status were obtained from clinical notes for a sample of cases. Cox regression was used to examine the association of the clinical variables and the 10-yr periods of disease onset with survival after diagnosis. Survival was inversely related to age, being worse for males (hazard ratio (HR) 1.4, 95% CI 1.2-1.6), and those with peritoneal mesothelioma (HR 1.4, 95% CI 1.1-1.7). Patients with sarcomatoid histology had worse prognosis than patients with epithelioid and biphasic histological subtypes. Survival improved after the 1970s and has made incremental improvements since then. Median (interquartile range) survival by decade, from 1960 until 2005, was 64 (0-198), 177 (48-350), 221 (97-504), 238 (108-502) and 301 (134-611) days; ~4 weeks of this apparent improvement can be attributed to earlier diagnosis. With increasing resources and treatment costs for MM over the past 40 yrs, there have been modest improvements in survival but no complete remissions. Copyright©ERS 2011.

    Related items

    Showing items related by title, author, creator and subject.

    • A multicentre non-blinded randomised controlled trial to assess the impact of regular early specialist symptom control treatment on quality of life in malignant mesothelioma (RESPECT-MESO): Study protocol for a randomised controlled trial
      Gunatilake, S.; Brims, Fraser; Fogg, C.; Lawrie, I.; Maskell, N.; Forbes, K.; Rahman, N.; Morris, S.; Ogollah, R.; Gerry, S.; Peake, M.; Darlison, L.; Chauhan, A. (2014)
      Background: Malignant pleural mesothelioma is an incurable cancer caused by exposure to asbestos. The United Kingdom has the highest death rate from mesothelioma in the world and this figure is increasing. Median survival ...
    • Novel strategies for inhibiting cancer growth
      Schaefer, Rainer (2008)
      At present, most cancers are treated with surgery, radiotherapy and chemotherapy, used alone or in combination. Surgery and radiotherapy are the primary treatment modalities after early detection of cancers and they ...
    • Familial aggregation of malignant mesothelioma in former workers and residents of Wittenoom, Western Australia
      De Klerk, N.; Alfonso, Helman; Olsen, N.; Reid, Alison; Sleith, J.; Palmer, L.; Berry, G.; Musk, A. (2013)
      Clustering of cases of malignant mesothelioma within families has often been observed, but disentangling genetic and exposure effects has not been done. Former workers and residents exposed to crocidolite at Wittenoom, ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.