The self-association of High Mobility Group Box 1 (HMGB1): Implications for interaction with Receptor for Advanced Glycation End-products (RAGE) and DNA
Access Status
Open access
Authors
Anggayasti, Wresti Listu
Date
2015Supervisor
Prof. Erik Helmerhorst
Dr Steven Bottomley
Prof. Ricardo Mancera
Type
Thesis
Award
PhD
Metadata
Show full item recordSchool
School of Biomedical Sciences
Collection
Abstract
High Mobility Group Box 1 (HMGB1) plays key roles in inflammatory diseases including cancer and diabetes. Intracellularly, HMGB1 binds DNA and assists transcription. Extracellularly, HMGB1 promotes inflammatory responses by binding to receptors such as the Receptor of Advanced Glycation End-products (RAGE). HMGB1 specifically self-associates in Surface Plasmon Resonance (SPR). The self-association is markedly influenced by ionic strength, redox, zinc ions, and pH. The role of HMGB1 self-association in binding DNA or RAGE is discussed.
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