The self-association of High Mobility Group Box 1 (HMGB1): Implications for interaction with Receptor for Advanced Glycation End-products (RAGE) and DNA
MetadataShow full item record
High Mobility Group Box 1 (HMGB1) plays key roles in inflammatory diseases including cancer and diabetes. Intracellularly, HMGB1 binds DNA and assists transcription. Extracellularly, HMGB1 promotes inflammatory responses by binding to receptors such as the Receptor of Advanced Glycation End-products (RAGE). HMGB1 specifically self-associates in Surface Plasmon Resonance (SPR). The self-association is markedly influenced by ionic strength, redox, zinc ions, and pH. The role of HMGB1 self-association in binding DNA or RAGE is discussed.
Showing items related by title, author, creator and subject.
The effect of physicochemical factors on the self-association of HMGB1: A surface plasmon resonance studyAnggayasti, W.; Mancera, Ricardo; Bottomley, S.; Helmerhorst, Erik (2016)© 2016 Elsevier B.V. HMGB1 triggers proinflammatory reactions by interacting extracellularly with various receptors. HMGB1 also acts in the nucleus by interacting with DNA and controlling DNA transcription, a process which ...
The self-association of HMGB1 and its possible role in the binding to DNA and cell membrane receptorsAnggayasti, Wresti Listu; Mancera, Ricardo; Bottomley, Steven; Helmerhorst, Erik (2017)© 2016 Federation of European Biochemical SocietiesHigh mobility group box 1 (HMGB1), a chromatin protein, interacts with DNA and controls gene expression. However, when HMGB1 is released from apoptotic or damaged cells, ...
Postpolymerization synthesis of (bis)amide (co)polymers: Thermoresponsive behavior and self-associationZhu, Y.; Lowe, A.; Roth, Peter (2014)A library of novel well-defined (bis)amide-based (co)polymers was prepared through postpolymerization modification of poly(pentafluorophenyl acrylate) with amines including ammonia and amide derivatives of amino acids. ...