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    The self-association of High Mobility Group Box 1 (HMGB1): Implications for interaction with Receptor for Advanced Glycation End-products (RAGE) and DNA

    233994_Anggayasti 2015 3 years.pdf (3.899Mb)
    Access Status
    Open access
    Authors
    Anggayasti, Wresti Listu
    Date
    2015
    Supervisor
    Prof. Erik Helmerhorst
    Dr Steven Bottomley
    Prof. Ricardo Mancera
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/2004
    Collection
    • Curtin Theses
    Abstract

    High Mobility Group Box 1 (HMGB1) plays key roles in inflammatory diseases including cancer and diabetes. Intracellularly, HMGB1 binds DNA and assists transcription. Extracellularly, HMGB1 promotes inflammatory responses by binding to receptors such as the Receptor of Advanced Glycation End-products (RAGE). HMGB1 specifically self-associates in Surface Plasmon Resonance (SPR). The self-association is markedly influenced by ionic strength, redox, zinc ions, and pH. The role of HMGB1 self-association in binding DNA or RAGE is discussed.

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