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dc.contributor.authorSaraswati, H.
dc.contributor.authorLee, Silvia
dc.contributor.authorTan, D.
dc.contributor.authorYunihastuti, E.
dc.contributor.authorGani, R.
dc.contributor.authorPrice, Patricia
dc.date.accessioned2017-01-30T12:18:27Z
dc.date.available2017-01-30T12:18:27Z
dc.date.created2015-12-10T04:26:07Z
dc.date.issued2015
dc.identifier.citationSaraswati, H. and Lee, S. and Tan, D. and Yunihastuti, E. and Gani, R. and Price, P. 2015. Increased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART. Human Immunology. 77 (1): pp. 29-34.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/20295
dc.identifier.doi10.1016/j.humimm.2015.10.002
dc.description.abstract

Dendritic cell (DC) numbers and functions can be affected by HIV and HCV disease, but the effects of antiretroviral therapy (ART) on DC and the implications of these changes are unclear. We examined circulating DC in samples from Indonesian patients beginning ART with advanced HIV disease and documented mild/moderate HCV hepatitis. Frequencies of myeloid and plasmacytoid DC increased after 6 months on ART, but frequencies of DC producing IL-12 or IFNα following stimulation with TLR agonists (CL075, CpG) did not change. IFNγ responses to CL075, HCV and other antigens rose over this period. Hence increased IFNγ responses during ART may be associated with increased DC frequencies rather than changes in their functional capacity.

dc.titleIncreased proportions of dendritic cells and recovery of IFNγ responses in HIV/HCV co-infected patients receiving ART
dc.typeJournal Article
dcterms.source.volumeIn Press
dcterms.source.startPage1
dcterms.source.endPage6
dcterms.source.issn0198-8859
dcterms.source.titleHuman Immunology
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access


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