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    The effectiveness of pulsed electrical stimulation (E-PES) in the management of osteoarthritis of the knee: a protocol for a randomised controlled trial

    215775_1471-2474-9-18.pdf (295.1Kb)
    Access Status
    Open access
    Authors
    Fary, Robyn
    Carroll, G.
    Briffa, T.
    Gupta, Ritu
    Briffa, Kathy
    Date
    2008
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Fary, R. and Carroll, G. and Briffa, T. and Gupta, R. and Briffa, K. 2008. The effectiveness of pulsed electrical stimulation (E-PES) in the management of osteoarthritis of the knee: a protocol for a randomised controlled trial. BMC Musculoskeletal Disorders. 9 (18).
    Source Title
    BMC Musculoskeletal Disorders
    DOI
    10.1186/1471-2474-9-18
    ISSN
    14712474
    School
    School of Physiotherapy and Exercise Science
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/. Please refer to the licence to obtain terms for any further reuse or distribution of this work.

    URI
    http://hdl.handle.net/20.500.11937/20331
    Collection
    • Curtin Research Publications
    Abstract

    Background: Osteoarthritis (OA) of the knee is one of the main causes of musculoskeletal disability in the western world. Current available management options provide symptomatic relief (exercise and self-management, medication and surgery) but do not, in general, address the disease process itself. Moreover, adverse effects and complications with some of these interventions (medication and surgery) and the presence of co-morbidities commonly restrict their use. There is clearly a need to investigate treatments that are more widely applicable for symptom management and which may also directly address the disease process itself. In two randomised controlled trials of four and 12 weeks duration, pulsed electrical stimulation was shown to be effective in managing the symptoms of OA of the knee. Laboratory and animal studies demonstrate the capacity of externally applied electric and electromagnetic fields to positively affect chondrocyte proliferation and extracellular matrix protein production. This latter evidence provides strong theoretical support for the use of electrical stimulation to maintain and repair cartilage in the clinical setting and highlights its potential as a disease-modifying modality.Methods/Design: A double-blind, randomised, placebo-controlled, repeated measures trial to examine the effectiveness of pulsed electrical stimulation in providing symptomatic relief for people with OA of the knee over 26 weeks. Seventy people will be recruited and information regarding age, gender, body mass index and medication use will be recorded. The population will be stratified for age, gender and baseline pain levels. Outcome measures will include pain (100 mm VAS and WOMAC 3.1), function (WOMAC 3.1), stiffness (WOMAC 3.1), patient global assessment (100 mm VAS) and quality of life (SF-36). These outcomes will be measured at baseline, four, 16 and 26 weeks. Activity levels will be measured at baseline and 16 weeks using accelerometers and the Human Activity Profile questionnaire. A patient global perceived effect scale (11-point Likert) will be completed at 16 and 26 weeks. Discussion: This paper describes the protocol for a randomised, double-blind, placebo-controlled trial that will contribute to the evidence regarding the use of sub-sensory pulsed electrical stimulation in the management of OA of the knee.

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    • The effectiveness of pulsed electrical stimulation in the management of osteoarthritis of the knee
      Fary, Robyn (2010)
      Osteoarthritis of the knee is a chronic disease leading to considerable burden on health. Pain, while not always present is the most prominent clinical feature and the cause of significant disability. There are a wide ...
    • The Effectiveness of Pulsed Electrical Stimulation in the Management of Osteoarthritis of the Knee: Results of a Double-Blind, Randomised, Placebo-Controlled Repeated-Measures Trial
      Fary, Robyn; Carroll, G.; Briffa, T.; Briffa, Kathy (2011)
      Objective: To determine the effectiveness of subsensory, pulsed electrical stimulation (PES) in the symptomatic management of osteoarthritis (OA) of the knee. Methods: This was a double-blind, randomized, placebo-controlled, ...
    • Effects of self-management, education and specific exercises, delivered by health professionals, in patients with osteoarthritis of the knee
      Coleman, S.; Briffa, Kathy; Carroll, G.; Inderjeeth, C.; Cook, N.; McQuade, J. (2008)
      Background. An education self-management program for people with osteoarthritis (OA) of the knee was designed to be delivered by health professionals, incorporating their knowledge and expertise. Improvement in quality ...
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