Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases

    Access Status
    Fulltext not available
    Authors
    Kaskow, B.
    Michael Proffit, J.
    Blangero, J.
    Moses, Eric
    Abraham, L.
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Kaskow, B. and Michael Proffit, J. and Blangero, J. and Moses, E. and Abraham, L. 2012. Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases. Biochemical and Biophysical Research Communications. 417 (2): pp. 653-658.
    Source Title
    Biochemical and Biophysical Research Communications
    DOI
    10.1016/j.bbrc.2011.11.099
    ISSN
    0006-291X
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/20391
    Collection
    • Curtin Research Publications
    Abstract

    The Vanin genes are a family that encode pantetheinases involved in recycling Coenzyme A, catalysing the breakdown of intermediate pantetheine to vitamin B5 for reuse in CoA biosynthesis. The role of pantetheinase in this most fundamental of cellular processes, was substantially characterised by the 1970s. The next 20 years saw little further interest in pantetheinase until various genetic studies implicated the Vanin locus in a range of normal and disease phenotypes, and a consequent interest in the other product of pantetheinase activity, cysteamine. This report seeks to bring together the early biochemical studies with recent biological data implicating cysteamine as a regulator of the oxidative state of a cell. Numerous studies now report a role for Vanin in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease.

    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.