Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Systematic review: Relationships between sleep and gastro-oesophageal reflux

    Access Status
    Open access via publisher
    Authors
    Dent, J.
    Holloway, R.
    Eastwood, Peter
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Dent, J. and Holloway, R. and Eastwood, P. 2013. Systematic review: Relationships between sleep and gastro-oesophageal reflux. Alimentary Pharmacology and Therapeutics. 38 (7): pp. 657-673.
    Source Title
    Alimentary Pharmacology and Therapeutics
    DOI
    10.1111/apt.12445
    ISSN
    0269-2813
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/20696
    Collection
    • Curtin Research Publications
    Abstract

    Background Gastro-oesophageal reflux disease (GERD) adversely impacts on sleep, but the mechanism remains unclear. Aim To review the literature concerning gastro-oesophageal reflux during the sleep period, with particular reference to the sleep/awake state at reflux onset. Methods Studies identified by systematic literature searches were assessed. Results Overall patterns of reflux during the sleep period show consistently that oesophageal acid clearance is slower, and reflux frequency and oesophageal acid exposure are higher in patients with GERD than in healthy individuals. Of the 17 mechanistic studies identified by the searches, 15 reported that a minority of reflux episodes occurred during stable sleep, but the prevailing sleep state at the onset of reflux in these studies remains unclear owing to insufficient temporal resolution of recording or analysis methods. Two studies, in healthy individuals and patients with GERD, analysed sleep and pH with adequate resolution for temporal alignment of sleep state and the onset of reflux: all 232 sleep period reflux episodes evaluated occurred during arousals from sleep lasting less than 15 s or during longer duration awakenings. Six mechanistic studies found that transient lower oesophageal sphincter relaxations were the most common mechanism of sleep period reflux. Conclusions Contrary to the prevailing view, subjective impairment of sleep in GERD is unlikely to be due to the occurrence of reflux during stable sleep, but could result from slow clearance of acid reflux that occurs during arousals or awakenings from sleep. Definitive studies are needed on the sleep/awake state at reflux onset across the full GERD spectrum. © 2013 John Wiley & Sons Ltd.

    Related items

    Showing items related by title, author, creator and subject.

    • Obstructive sleep apnoea and nocturnal gastroesophageal reflux are common in lung transplant patients
      Shepherd, K.; Chambers, D.; Gabbay, E.; Hillman, D.; Eastwood, Peter (2008)
      Background and objective: Gastroesophageal reflux (GOR) has been implicated in the pathogenesis of bronchiolitis obliterans syndrome (BOS), possibly due to pulmonary aspiration of refluxed acid. Risk of aspiration of ...
    • Gastro-oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoea
      Shepherd, K.; James, A.; Musk, A.; Hunter, M.; Hillman, D.; Eastwood, Peter (2011)
      Repetitive airway occlusion during sleep in patients with obstructive sleep apnoea (OSA) results in the generation of negative intrathoracic pressures and ends in arousal, both of which may predispose to reflux during ...
    • Laboratory and home comparison of wrist-activity monitors and polysomnography in middle-aged adults
      Dunican, I.; Murray, K.; Slater, J.; Maddison, K.; Jones, M.; Dawson, B.; Straker, Leon; Caldwell, J.; Halson, S.; Eastwood, P. (2018)
      © 2017, Japanese Society of Sleep Research. Accurate measurement of time at lights out is essential for calculation of several measures of sleep in wrist-activity monitors. While some devices use subjective reporting of ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.