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    Vancomycin minimum inhibitory concentration, host comorbidities and mortality in staphylococcus aureus bacteraemia

    Access Status
    Open access via publisher
    Authors
    Holmes, N.
    Turnidge, J.
    Munckhof, W.
    Robinson, James
    Korman, T.
    O'Sullivan, M.
    Anderson, T.
    Roberts, S.
    Warren, S.
    Gao, W.
    Johnson, P.
    Howden, B.
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Holmes, N. and Turnidge, J. and Munckhof, W. and Robinson, J. and Korman, T. and O'Sullivan, M. and Anderson, T. et al. 2013. Vancomycin minimum inhibitory concentration, host comorbidities and mortality in staphylococcus aureus bacteraemia. Clinical Microbiology and Infection. 19 (12): pp. 1163-1168.
    Source Title
    Clinical Microbiology and Infection
    DOI
    10.1111/1469-0691.12168
    ISSN
    1198-743X
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/20840
    Collection
    • Curtin Research Publications
    Abstract

    We reported an association between elevated vancomycin MIC and 30-day mortality in patients with Staphylococcus aureus bacteraemia (SAB), including patients with methicillin-susceptible S. aureus (MSSA) treated with flucloxacillin. A detailed analysis of comorbidities and disease severity scores in the same cohort of patients was performed to ascertain if unknown clinical parameters may have influenced these results. The association between elevated vancomycin MIC and 30-day mortality in SAB remained significant (p 0.001) on multivariable logistic regression analysis even when accounting for clinical factors. In addition, the association persisted when restricting analysis to patients with MSSA bacteraemia treated with flucloxacillin. This suggests that elevated vancomycin MIC is associated with but not causally linked to an organism factor that is responsible for increased mortality. © 2013 European Society of Clinical Microbiology and Infectious Diseases.

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