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The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

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Authors
Qiu, W.
Pham, K.
James, Ian
Nolan, D.
Castley, A.
Christiansen, F.
Czarniak, Petra
Luo, Y.
Wu, J.
Garlepp, Michael
Wilton, S.
Carroll, W.
Mastaglia, F.
Kermode, A.
Date
2013
Type
Journal Article

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Qiu, Wei and Pham, Kym and James, Ian and Nolan, David and Castley, Allison and Christiansen, Frank Y. and Czarniak, Petra et al. 2013. The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort. Journal of Neuroimmunology. 261 (1-2): pp. 92-97.
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Journal of Neuroimmunology
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Abstract

Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/CD58, CLEC-16A/CTLA-4, and TYK2/IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups.