Polymorphisms detected in the tyrosinase and matp (slc45a2) genes did not explain coat colour dilution in a sample of Alpaca (Vicugna pacos)
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The molecular basis of the inheritance of alpaca fibre colour is poorly understood. It is likely that colour dilution is having an influence on alpaca fibre colour, with all primarily pheomelanic animals differing mainly in their total melanin concentration, as opposed to relative concentrations of pheomelanin and eumelanin. Candidate genes to cause such dilution include tyrosinase (tyr) and membrane associated transport protein (matp), both of which have been associated with coat colour dilution in other species. PCR primers were designed in regions surrounding each exon of tyr and matp and these exons were sequenced in 24 animals with dilute or non-dilute colour phenotypes from around Australia. No polymorphism found in the coding region of any tyr or matp exon was associated with dilution in fibre colour.
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Polymorphisms Detected in the Tyrosinase and MATP (SLC45A2) Genes Did Not Explain Coat Colour Dilution in a Sample of Alpaca (Vicugna pacos)Cransberg, R.; Munyard, Kylie (2009)The molecular basis of inheritance of alpaca fibre colour is poorly understood. However, colour dilution genes are anticipated to be causing a major effect on alpaca fibre colour. Candidate genes for dilutions included ...
Novel mutations in Vicugna pacos (alpaca) Tyrp1 are not correlated with brown fibre colour phenotypesFeeley, Natasha; Bottomley, Steven; Munyard, Kylie (2016)© 2016 Elsevier B.V. The tyrosinase related protein 1 (Tyrp1) gene is a logical candidate to house the causative mutation for the brown fibre colour phenotype that exists in alpacas. Polymorphisms in Tyrp1 have been ...
Munyard, Kylie (2013)This RIRDC report describes the research conducted as part of the alpaca colour genetics project to identify the genes involved in the inheritance of white colour in alpacas. Three approaches were used (Mendelian, physical ...