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    Blood naltrexone levels over time following naltrexone implant

    Access Status
    Fulltext not available
    Authors
    Ngo, H.
    Arnold-Reed, D.
    Hansson, R.
    Tait, Robert
    Hulse, G.
    Date
    2008
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Ngo, H. and Arnold-Reed, D. and Hansson, R. and Tait, R. and Hulse, G. 2008. Blood naltrexone levels over time following naltrexone implant. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32 (1): pp. 23-28.
    Source Title
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
    DOI
    10.1016/j.pnpbp.2007.06.007
    ISSN
    0278-5846
    School
    National Drug Research Institute (NDRI)
    URI
    http://hdl.handle.net/20.500.11937/21334
    Collection
    • Curtin Research Publications
    Abstract

    Aims: Oral naltrexone is used in the management of both heroin and alcohol dependence. However, poor compliance has limited its clinical utility. The study's objective was to determine the period of therapeutic coverage (= 2 ng/ml) provided by a 3.3 g naltrexone subcutaneous implant compared with existing data on 1.1 g and 2.2 g implants. Methods: We assessed free blood naltrexone levels following treatment with a 3.3 g naltrexone implant in heroin dependent patients (n = 50) in Perth, Western Australia. Results were compared with previously collated data for patients treated with either a 1.1 g (n = 10) or 2.2 g (n = 24) implant. Results: Following 3.3 g naltrexone implant treatment, free blood naltrexone levels remained above 2 ng/ml for 145 days (95% CI 125-167). In comparison, 1.1 g or 2.2 g implant treatment resulted in 95 days (95% CI 69-121) and 136 days (95% CI 114-158) coverage, respectively. Conclusions: The 3.3 g implant provides longer therapeutic coverage than the 1.1 g implant but not significantly longer than the 2.2 g implant. © 2007 Elsevier Inc. All rights reserved.

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