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dc.contributor.authorHenry, L.
dc.contributor.authorSchneider, C.
dc.contributor.authorMützel, B.
dc.contributor.authorSimpson, Peter
dc.contributor.authorNagel, C.
dc.contributor.authorFucke, K.
dc.contributor.authorSchatzschneider, U.
dc.date.accessioned2017-01-30T12:25:19Z
dc.date.available2017-01-30T12:25:19Z
dc.date.created2016-02-01T00:47:11Z
dc.date.issued2014
dc.identifier.citationHenry, L. and Schneider, C. and Mützel, B. and Simpson, P. and Nagel, C. and Fucke, K. and Schatzschneider, U. 2014. Amino acid bioconjugation via iClick reaction of an oxanorbornadiene-masked alkyne with a MnI(bpy)(CO)3-coordinated azide. Chemical Communications. 50 (99): pp. 15692-15695.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/21454
dc.identifier.doi10.1039/c4cc07892f
dc.description.abstract

The catalyst-free room temperature iClick reaction of an unsymmetrically 2,3-disubstituted oxanorbornadiene (OND) as a “masked” alkyne equivalent with [Mn(N3)(bpyCH3,CH3)(CO)3] leads to isolation of a phenylalanine ester bioconjugate, in which the model amino acid is linked to the metal moiety via a N-2-coordinated triazolate formed in a cycloaddition-retro-Diels–Alder (crDA) reaction sequence, in a novel approach to bioorthogonal coupling reactions based on metal-centered reactivity.

dc.titleAmino acid bioconjugation via iClick reaction of an oxanorbornadiene-masked alkyne with a MnI(bpy)(CO)3-coordinated azide
dc.typeJournal Article
dcterms.source.volume50
dcterms.source.number99
dcterms.source.startPage15692
dcterms.source.endPage15695
dcterms.source.issn1359-7345
dcterms.source.titleChemical Communications
curtin.departmentNanochemistry Research Institute
curtin.accessStatusFulltext not available


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