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    Stereoselective synthesis towards unnatural proline-based amino acids

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    Access Status
    Open access
    Authors
    Makhathini, S.
    Das, S.
    Singh, T.
    Arvidsson, P.
    Kruger, H.
    Gunosewoyo, Hendra
    Govender, T.
    Naicker, T.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Abstract

    A catalytic diastereoselective Mannich reaction promoted by chiral bifunctional urea-type organocatalysts has been developed. Treatment of N-Boc-3-ketoproline with N-Boc-aldimines under mild conditions afforded the corresponding unnatural proline based amino acid derivatives with excellent diastereoselectivities (up to 99:1) and enantioselectivities (up to 97% ee). The relative configuration of the chiral reaction products was deduced by the comparsion of the experimentally observed ECD spectra to that obtained theorectically.

    Citation
    Makhathini, S. and Das, S. and Singh, T. and Arvidsson, P. and Kruger, H. and Gunosewoyo, H. and Govender, T. et al. 2016. Stereoselective synthesis towards unnatural proline-based amino acids. Arkivoc. 2016 (3): pp. 134-144.
    Source Title
    Arkivoc
    DOI
    10.3998/ark.5550190.p009.462
    ISSN
    1551-7004
    School
    School of Pharmacy
    Remarks

    This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by-nc/3.0/

    URI
    http://hdl.handle.net/20.500.11937/21516
    Collection
    • Curtin Research Publications

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