Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling

    Access Status
    Fulltext not available
    Authors
    Bankaitis, V.
    Mousley, Carl
    Schaaf, G.
    Date
    2010
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Bankaitis, V. and Mousley, C. and Schaaf, G. 2010. The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling. Trends in Biochemical Sciences. 35 (3): pp. 150-160.
    Source Title
    Trends in Biochemical Sciences
    DOI
    10.1016/j.tibs.2009.10.008
    ISSN
    0968-0004
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/21659
    Collection
    • Curtin Research Publications
    Abstract

    Lipid signaling pathways define central mechanisms for cellular regulation. Productive lipid signaling requires an orchestrated coupling between lipid metabolism, lipid organization and the action of protein machines that execute appropriate downstream reactions. Using membrane trafficking control as primary context, we explore the idea that the Sec14-protein superfamily defines a set of modules engineered for the sensing of specific aspects of lipid metabolism and subsequent transduction of 'sensing' information to a phosphoinositide-driven 'execution phase'. In this manner, the Sec14 superfamily connects diverse territories of the lipid metabolome with phosphoinositide signaling in a productive 'crosstalk' between these two systems. Mechanisms of crosstalk, by which non-enzymatic proteins integrate metabolic cues with the action of interfacial enzymes, represent unappreciated regulatory themes in lipid signaling. © 2009 Elsevier Ltd. All rights reserved.

    Related items

    Showing items related by title, author, creator and subject.

    • A Molecular Probe for the Detection of Polar Lipids in Live Cells.
      Bader, C.; Shandala, T.; Carter, E.; Ivask, A.; Guinan, T.; Hickey, S.; Werrett, M.; Wright, Phillip; Simpson, Peter; Stagni, S.; Voelcker, N.; Lay, P.; Massi, Massimiliano; Plush, S.; Brooks, D. (2016)
      Lipids have an important role in many aspects of cell biology, including membrane architecture/compartment formation, intracellular traffic, signalling, hormone regulation, inflammation, energy storage and metabolism. ...
    • Nutrient regulation of insulin secretion and action
      Newsholme, Philip; Cruzat, Vinicius; Arfuso, Frank; Keane, Kevin (2014)
      Pancreatic ß-cell function is of critical importance in the regulation of fuel homoeostasis, and metabolic dysregulation is a hallmark of diabetes mellitus (DM). The ß-cell is an intricately designed cell type that couples ...
    • Pharmacological Applications of Bile Acids and Their Derivatives in the Treatment of Metabolic Syndrome
      Danic, M.; Stanimirov, B.; Pavlovic, N.; Golocorbin-Kon, S.; Al-Salami, Hani; Stankov, K.; Mikov, M. (2018)
      Apart from well-known functions of bile acids in digestion and solubilization of lipophilic nutrients and drugs in the small intestine, the emerging evidence from the past two decades identified the role of bile acids as ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.