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dc.contributor.authorSchultz, E.
dc.contributor.authorDevadason, S.
dc.contributor.authorKhoo, S.
dc.contributor.authorZhang, Guicheng
dc.contributor.authorBizzintino, J.
dc.contributor.authorMartin, A.
dc.contributor.authorGoldblatt, J.
dc.contributor.authorLaing, I.
dc.contributor.authorLe Souf, P.
dc.contributor.authorHayden, C.
dc.date.accessioned2017-01-30T12:27:17Z
dc.date.available2017-01-30T12:27:17Z
dc.date.created2016-09-12T08:36:29Z
dc.date.issued2010
dc.identifier.citationSchultz, E. and Devadason, S. and Khoo, S. and Zhang, G. and Bizzintino, J. and Martin, A. and Goldblatt, J. et al. 2010. Environmental determinants - The role of GSTP1 polymorphisms and tobacco smoke exposure in children with acute asthma. Journal of Asthma. 47 (9): pp. 1049-1056.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/21760
dc.identifier.doi10.1080/02770903.2010.508856
dc.description.abstract

Background. The glutathione S-transferase enzymes (GSTs) play an important role in the detoxification of environmental tobacco smoke (ETS), which contributes to airway inflammation, a key component of asthma. Genetic variation in GST genes may influence individuals' ability to detoxify environmental pollutants. Objective. To examine the role of polymorphisms in GSTP1 (Ile105Val and Ala114Val), alone and in combination with ETS exposure, on atopy and asthma severity. Methods. GSTP1 Ile105Val and Ala114Val were genotyped and ETS exposure was assessed by parental questionnaire, which was validated by urinary cotinine measurements. Associations between ETS exposure, GSTP1 polymorphisms, and their interaction on atopy and asthma severity were investigated. Results. For the functional GSTP1 105 SNP, those with the Ile/Ile genotype had odds for atopy of 2.77 (p=.054) when assessed by genotype alone, which increased to 9.02 (p=.050) when ETS was included, relative to individuals with other genotypes. Likewise, compared to children with other GSTP1 114 genotypes, those with AlaAla genotype had a 5.47-fold (p=.002) increased risk of atopy (p=.020) when assessed by genotype alone, increasing to 9.17-fold when ETS was included. The 105 Ile/Ile individuals all had the AA (105 Ile/Ile and 114 AlaAla) haplotype group; therefore, the odds for atopy were the same. Individuals without any *C haplotype (105 Val and 114 Val allele) who were exposed to ETS had a 9.17-fold increased risk of atopy when compared with individuals with at least one *C haplotype and not exposed to ETS (p=.020). Conclusion. There were significant interactions between GSTP1 SNPs, atopy, and ETS exposure in this cohort. © 2010 Informa Healthcare USA, Inc.

dc.publisherInforma Healthcare
dc.titleEnvironmental determinants - The role of GSTP1 polymorphisms and tobacco smoke exposure in children with acute asthma
dc.typeJournal Article
dcterms.source.volume47
dcterms.source.number9
dcterms.source.startPage1049
dcterms.source.endPage1056
dcterms.source.issn0277-0903
dcterms.source.titleJournal of Asthma
curtin.departmentSchool of Public Health
curtin.accessStatusFulltext not available


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