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    Primary acute dengue and the deletion in chemokine receptor 5 (CCR5D32)

    Access Status
    Fulltext not available
    Authors
    Brestovac, Brian
    Harris, R.
    Halicki, Larissa
    Sampson, I.
    Speers, D.
    Mamotte, Cyril
    Williams, David
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Brestovac, B. and Halicki, L. and Harris, R. and Sampson, I. and Speers, D. and Mamotte, C. and Williams, D. 2014. Primary acute dengue and the deletion in chemokine receptor 5 (CCR5Δ32). Microbes and Infection. 16 (6): pp. 518-521.
    Source Title
    Microbes and Infection
    DOI
    10.1016/j.micinf.2014.02.007
    ISSN
    12864579
    URI
    http://hdl.handle.net/20.500.11937/21764
    Collection
    • Curtin Research Publications
    Abstract

    Dengue virus is a significant arboviral pathogen that is continuing to spread due to human travel and invasion of the mosquito vectors into new regions. Chemokine receptor 5 (CCR5) has a truncated 32 base pair deletion form (CCR5Δ32), which has been associated with resistance to HIV but increased severity in some flaviviral diseases. If CCR5Δ32 is associated with dengue, European carriers of this mutation may be at increased risk. In a Western Australian population with the same frequency of CCR5Δ32 (0.08) as that found in southern Europe there was no significant difference in CCR5Δ32 allele frequency between returned travellers with and without dengue (p = 0.82, OR = 0.86, 95% CI = 0.35–2.1).

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