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dc.contributor.authorElsegood, Caryn
dc.contributor.authorChang, M.
dc.contributor.authorJessup, W.
dc.contributor.authorScholz, G.
dc.contributor.authorHamilton, J.
dc.date.accessioned2017-01-30T12:27:31Z
dc.date.available2017-01-30T12:27:31Z
dc.date.created2016-09-12T08:36:25Z
dc.date.issued2009
dc.identifier.citationElsegood, C. and Chang, M. and Jessup, W. and Scholz, G. and Hamilton, J. 2009. Glucose metabolism is required for oxidized LDL-induced macrophage survival: Role of PI3K and Bcl-2 family proteins. Arteriosclerosis, Thrombosis, and Vascular Biology. 29 (9): pp. 1283-1289.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/21809
dc.identifier.doi10.1161/ATVBAHA.108.180778
dc.description.abstract

OBJECTIVE-: Oxidized low-density lipoprotein (oxLDL) induces survival of colony stimulating factor-1 (CSF-1)-dependent macrophages in vitro. Because atherosclerotic lesion-associated macrophages take up large amounts of glucose, we investigated whether, and how, oxLDL promotes glucose uptake and how glucose metabolism regulates oxLDL-induced macrophage survival. METHODS AND RESULTS-: OxLDL-induced macrophage survival required glucose metabolism. OxLDL stimulated 2 phases of glucose uptake, namely acute and chronic, which required PI3K but not MEK1/2 activity. PI3K appeared to regulate glucose transport via glucose transporter affinity and/or mobilization. OxLDL also maintained levels of the prosurvival proteins, Bcl-2 and Bcl-xL, after CSF-1 had been removed through a combination of mechanisms including transcription, translation, and protein stabilization. Significantly, inhibition of glucose metabolism reduced Bcl-2 and Bcl-xL protein levels. MEK1/2 and PI3K activities were also required for oxLDL-induced Bcl-2 and Bcl-xL mRNA upregulation. CONCLUSIONS-: These results suggest that oxLDL enhances macrophage survival in the absence of CSF-1 by inducing PI3K-dependent glucose uptake, which is metabolized to maintain Bcl-2 and Bcl-xL protein levels. © 2009 American Heart Association, Inc.

dc.publisherLippincott Williams & Wilkins
dc.titleGlucose metabolism is required for oxidized LDL-induced macrophage survival: Role of PI3K and Bcl-2 family proteins
dc.typeJournal Article
dcterms.source.volume29
dcterms.source.number9
dcterms.source.startPage1283
dcterms.source.endPage1289
dcterms.source.issn1079-5642
dcterms.source.titleArteriosclerosis, Thrombosis, and Vascular Biology
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher


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