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    Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt

    233728.pdf (187.7Kb)
    Access Status
    Open access
    Authors
    Visweswaran, Malini
    Pohl, Sebastian
    Arfuso, Frank
    Newsholme, Philip
    Dilley, R.
    Pervaiz, S.
    Dharmarajan, Arunasalam
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Visweswaran, M. and Pohl, S. and Arfuso, F. and Newsholme, P. and Dilley, R. and Pervaiz, S. and Dharmarajan, A. 2015. Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt. The International Journal of Biochemistry & Cell Biology. 68: pp. 139-147.
    Source Title
    The International Journal of Biochemistry & Cell Biology
    DOI
    10.1016/j.biocel.2015.09.008
    School
    School of Biomedical Sciences
    Curtin Health Innovation Research Institute
    URI
    http://hdl.handle.net/20.500.11937/22581
    Collection
    • Curtin Research Publications
    Abstract

    Mesenchymal stem cells (MSCs) are multipotent precursor cells originating from several adult connective tissues. MSCs possess the ability to self-renew and differentiate into several lineages, and are recognized by the expression of unique cell surface markers. Several lines of evidence suggest that various signal transduction pathways and their interplay regulate MSC differentiation. To that end, a critical player in regulating MSC differentiation is a group of proteins encoded by the Wnt gene family, which was previously known for influencing various stages of embryonic development and cell fate determination. As MSCs have gained significant clinical attention for their potential applications in regenerative medicine, it is imperative to unravel the mechanisms by which molecular regulators control differentiation of MSCs for designing cell-based therapeutics. It is rather coincidental that the functional outcome(s) of Wnt-induced signals share similarities with cellular redox-mediated networks from the standpoint of MSC biology. Furthermore, there is evidence for a crosstalk between Wnt and redox signalling, which begs the question whether Wnt-mediated differentiation signals involve the intermediary role of reactive oxygen species. In this review, we summarize the impact of Wnt signalling on multi-lineage differentiation of MSCs, and attempt to unravel the intricate interplay between Wnt and redox signals.

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