RAFT polymerization and thiol chemistry: A complementary pairing for implementing modern macromolecular design
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Reversible addition fragmentation chain transfer (RAFT) polymerization is one of the most extensively studied reversible deactivation radical polymerization methods for the production of well-defined polymers. After polymerization, the RAFT agent end-group can easily be converted into a thiol, opening manifold opportunities for thiol modification reactions. This review is focused both on the introduction of functional end-groups using well-established methods, such as thiol-ene chemistry, as well as on creating bio-cleavable disulfide linkages via disulfide exchange reactions. We demonstrate that thiol modification is a highly attractive and efficient chemistry for modifying RAFT polymers.
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Sequential thiol-ene/thiol-ene and thol-ene/thiol-yne reactions as a route to well-defined mono and bis end-functionalized poly(N-isopropylacrylarnide)Yu, B.; Chan, J.; Hoyle, C.; Lowe, Andrew (2009)Sequential thiol-ene/thiol-ene and thiol-ene/thiol-yne reactions have been used as a facile and quantitative method for modifying end-groups on an N-isopro-pylacrylamide (NIPAm) homopolymer. A well-defined precursor of ...
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