Optical coherence elastography: Strain imaging in tissue using optical coherence tomography
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Optical coherence elastography (OCE) is a strain imaging technique that characterizes the elastic properties of tissues with microscopic resolution in three dimensions. In OCE, the displacement introduced to tissue by mechanical excitation is measured using optical coherence tomography. The local strain is calculated from the spatial derivative of displacement to generate strain images, known as elastograms. To validate elastograms, we compare them to a finite element analysis model of sample deformation. We also present preliminary OCE measurements performed on excised human breast tissue, and demonstrate discrimination of tissue types based on their elastic properties.
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Kennedy, Kelsey; Ford, Chris; Kennedy, Brendan; Bush, Mark; Sampson, David (2013)Optical coherence elastography (OCE) maps the mechanical properties of tissue microstructure and has potential applications in both fundamental investigations of biomechanics and in clinical medicine. We report the first ...
Kennedy, K.; Kennedy, B.; McLaughlin, R.; Ford, Christopher; Bush, M.; Sampson, D. (2013)Optical coherence elastography (OCE) provides images of tissue elasticity and has potential for several clinical applications, including guidance of tumor resection. However, advancement toward clinical implementation of ...
Airway narrowing assessed by anatomical optical coherence tomography in vitro: Dynamic airway wall morphology and functionNoble, P.; West, A.; McLaughlin, R.; Armstrong, J.; Becker, S.; McFawn, P.; Williamson, J.; Eastwood, Peter; Hillman, D.; Sampson, D.; Mitchell, H. (2010)Regulation of airway caliber by lung volume or bronchoconstrictor stimulation is dependent on physiological, structural, and mechanical events within the airway wall, including airway smooth muscle (ASM) contraction, ...