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    Formulation and Characterization of Drug-Loaded Microparticles Using Distillers Dried Grain Kafirin

    Access Status
    Fulltext not available
    Authors
    Lau, E.
    Johnson, Stuart
    Stanley, R.
    Mereddy, R.
    Mikkelsen, D.
    Halley, P.
    Steadman, K.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Lau, E. and Johnson, S. and Stanley, R. and Mereddy, R. and Mikkelsen, D. and Halley, P. and Steadman, K. 2015. Formulation and Characterization of Drug-Loaded Microparticles Using Distillers Dried Grain Kafirin. Cereal Chemistry. 92 (3): pp. 246-252.
    Source Title
    Cereal Chemistry
    DOI
    10.1094/CCHEM-05-14-0096-R
    ISSN
    0009-0352
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/22668
    Collection
    • Curtin Research Publications
    Abstract

    Kafirin, a protein extracted from sorghum grain, has been formulated into microparticles and proposed for use as a delivery system owing to the resistance of kafirin to upper gastrointestinal digestion. However, extracting kafirin from sorghum distillers dried grains with solubles (DDGS) may be more efficient, because the carbohydrate component has been removed by fermentation. This study investigated the properties and use of kafirin extracted from DDGS to formulate microparticles. Prednisolone, an anti-inflammatory drug that could benefit from a delayed and targeted delivery system to the colon, was loaded into DDGS kafirin microparticles by phase separation with sodium chloride. Scanning electron micrographs revealed that the empty and prednisolone-loaded microparticles were round in shape and varied in size. Surface binding studies indicated prednisolone was loaded within the microparticles rather than being solely bound on the surface. These findings demonstrate DDGS kafirin can be formulated into microparticles and loaded with medication. Future studies could investigate the potential applications of DDGS kafirin microparticles as an orally administered targeted drug-delivery system.

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    • Optimizing prednisolone loading into distiller’s dried grain kafirin microparticles, and in vitro release for oral delivery
      Lau, E.; Johnson, Stuart; Williams, B.; Mikkelsen, D.; McCourt, E.; Stanley, R.; Mereddy, R.; Halley, P.; Steadman, K. (2017)
      Kafirin microparticles have potential as colon-targeted delivery systems because of their ability to protect encapsulated material from digestive processes of the upper gastrointestinal tract (GIT). The aim was to optimize ...
    • Preparation and In Vitro Release of Drug-Loaded Microparticlesfor Oral Delivery Using Wholegrain Sorghum Kafirin Protein
      Lau, E.; Johnson, Stuart; Stanley, R.; Mikkelsen, D.; Fang, Zhongxiang; Halley, P.; Steadman, K. (2015)
      Kafirin microparticles have been proposed as an oral nutraceutical and drug delivery system. This study investigates microparticles formed with kafirin extracted from white and raw versus cooked red sorghum grains as an ...
    • Encapsulation of hydrocortisone and mesalazine in zein microparticles
      Lau, E.; Giddings, S.; Mohammed, S.; Dubois, Paul; Johnson, Stuart; Stanley, R.; Halley, P.; Steadman, K. (2013)
      Zein was investigated for use as an oral-drug delivery system by loading prednisolone into zein microparticles using coacervation. To investigate the adaptability of this method to other drugs, zein microparticles were ...
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