Formulation and Characterization of Drug-Loaded Microparticles Using Distillers Dried Grain Kafirin
MetadataShow full item record
Kafirin, a protein extracted from sorghum grain, has been formulated into microparticles and proposed for use as a delivery system owing to the resistance of kafirin to upper gastrointestinal digestion. However, extracting kafirin from sorghum distillers dried grains with solubles (DDGS) may be more efficient, because the carbohydrate component has been removed by fermentation. This study investigated the properties and use of kafirin extracted from DDGS to formulate microparticles. Prednisolone, an anti-inflammatory drug that could benefit from a delayed and targeted delivery system to the colon, was loaded into DDGS kafirin microparticles by phase separation with sodium chloride. Scanning electron micrographs revealed that the empty and prednisolone-loaded microparticles were round in shape and varied in size. Surface binding studies indicated prednisolone was loaded within the microparticles rather than being solely bound on the surface. These findings demonstrate DDGS kafirin can be formulated into microparticles and loaded with medication. Future studies could investigate the potential applications of DDGS kafirin microparticles as an orally administered targeted drug-delivery system.
Showing items related by title, author, creator and subject.
Optimizing prednisolone loading into distiller’s dried grain kafirin microparticles, and in vitro release for oral deliveryLau, E.; Johnson, Stuart; Williams, B.; Mikkelsen, D.; McCourt, E.; Stanley, R.; Mereddy, R.; Halley, P.; Steadman, K. (2017)© 2017 by the authors. Licensee MDPI, Basel, Switzerland. Kafirin microparticles have potential as colon-targeted delivery systems because of their ability to protect encapsulated material from digestive processes of the ...
Preparation and In Vitro Release of Drug-Loaded Microparticlesfor Oral Delivery Using Wholegrain Sorghum Kafirin ProteinLau, E.; Johnson, Stuart; Stanley, R.; Mikkelsen, D.; Fang, Zhongxiang; Halley, P.; Steadman, K. (2015)Kafirin microparticles have been proposed as an oral nutraceutical and drug delivery system. This study investigates microparticles formed with kafirin extracted from white and raw versus cooked red sorghum grains as an ...
Lau, E.; Giddings, S.; Mohammed, S.; Dubois, Paul; Johnson, Stuart; Stanley, R.; Halley, P.; Steadman, K. (2013)Zein was investigated for use as an oral-drug delivery system by loading prednisolone into zein microparticles using coacervation. To investigate the adaptability of this method to other drugs, zein microparticles were ...